TCF7L2 rs290487 C allele aberrantly enhances hepatic gluconeogenesis through allele-specific changes in transcription and chromatin binding

In this study, we investigated the mechanisms underlying the altered hepatic glucose metabolism and enhanced diabetes risk in individuals with the TCF7L2 rs290487 C allele. Analysis of 195 cirrhotic patients revealed a higher insulin resistance index and incidence of hepatogenous diabetes in patient...

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Detalles Bibliográficos
Autores principales: Zhang, Xueyou, Ye, Panpan, Huang, Haitao, Wang, Baohong, Dong, Fengqin, Ling, Qi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals 2020
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7377900/
https://www.ncbi.nlm.nih.gov/pubmed/32651957
http://dx.doi.org/10.18632/aging.103442

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7377900/
https://www.ncbi.nlm.nih.gov/pubmed/32651957
http://dx.doi.org/10.18632/aging.103442

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