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The function and mechanism of circular RNAs in gastrointestinal tumours
Gastrointestinal tumours are tumours that originate in the digestive tract and have extremely high morbidity and mortality. The main categories include: oesophageal, gastric, and colorectal cancers. Circular RNAs are a new class of non‐coding RNAs with a covalent closed‐loop structure without a 5’ c...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7377939/ https://www.ncbi.nlm.nih.gov/pubmed/32515024 http://dx.doi.org/10.1111/cpr.12815 |
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author | Nie, Hui Wang, Yutong Liao, Zhiming Zhou, Jianhua Ou, Chunlin |
author_facet | Nie, Hui Wang, Yutong Liao, Zhiming Zhou, Jianhua Ou, Chunlin |
author_sort | Nie, Hui |
collection | PubMed |
description | Gastrointestinal tumours are tumours that originate in the digestive tract and have extremely high morbidity and mortality. The main categories include: oesophageal, gastric, and colorectal cancers. Circular RNAs are a new class of non‐coding RNAs with a covalent closed‐loop structure without a 5’ cap or a 3’ poly A tail, which can encode a small amount of polypeptide. Recent studies have shown that circRNAs are involved in multiple biological processes during the development of gastrointestinal tumours including proliferation, invasion and metastasis, radio‐ and chemoresistance, and inflammatory responses. Also, the clinical and pathological characteristics of the patient, such as staging and lymph node metastasis, are closely associated with the expression level of circRNAs. Further investigation of the function and the role of circRNAs in the development of gastrointestinal tumours will provide new directions for its clinical diagnosis and treatment. |
format | Online Article Text |
id | pubmed-7377939 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-73779392020-07-27 The function and mechanism of circular RNAs in gastrointestinal tumours Nie, Hui Wang, Yutong Liao, Zhiming Zhou, Jianhua Ou, Chunlin Cell Prolif Reviews Gastrointestinal tumours are tumours that originate in the digestive tract and have extremely high morbidity and mortality. The main categories include: oesophageal, gastric, and colorectal cancers. Circular RNAs are a new class of non‐coding RNAs with a covalent closed‐loop structure without a 5’ cap or a 3’ poly A tail, which can encode a small amount of polypeptide. Recent studies have shown that circRNAs are involved in multiple biological processes during the development of gastrointestinal tumours including proliferation, invasion and metastasis, radio‐ and chemoresistance, and inflammatory responses. Also, the clinical and pathological characteristics of the patient, such as staging and lymph node metastasis, are closely associated with the expression level of circRNAs. Further investigation of the function and the role of circRNAs in the development of gastrointestinal tumours will provide new directions for its clinical diagnosis and treatment. John Wiley and Sons Inc. 2020-06-08 /pmc/articles/PMC7377939/ /pubmed/32515024 http://dx.doi.org/10.1111/cpr.12815 Text en © 2020 The Authors. Cell Proliferation Published by John Wiley & Sons Ltd. This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Reviews Nie, Hui Wang, Yutong Liao, Zhiming Zhou, Jianhua Ou, Chunlin The function and mechanism of circular RNAs in gastrointestinal tumours |
title | The function and mechanism of circular RNAs in gastrointestinal tumours |
title_full | The function and mechanism of circular RNAs in gastrointestinal tumours |
title_fullStr | The function and mechanism of circular RNAs in gastrointestinal tumours |
title_full_unstemmed | The function and mechanism of circular RNAs in gastrointestinal tumours |
title_short | The function and mechanism of circular RNAs in gastrointestinal tumours |
title_sort | function and mechanism of circular rnas in gastrointestinal tumours |
topic | Reviews |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7377939/ https://www.ncbi.nlm.nih.gov/pubmed/32515024 http://dx.doi.org/10.1111/cpr.12815 |
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