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Encephalopathy in severe SARS-CoV2 infection: Inflammatory or infectious?
Concerning the letter by Moriguchi et al., we describe our experience with a case of encephalopathy with and atypical damage on magnetic resonance imaging (MRI) in a patient with severe infection due to the SARS-CoV2 virus. A 56-year-old woman, without previous pathologies, developed cough, fever, a...
Autores principales: | , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The Author(s). Published by Elsevier Ltd on behalf of International Society for Infectious Diseases.
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7378010/ https://www.ncbi.nlm.nih.gov/pubmed/32712426 http://dx.doi.org/10.1016/j.ijid.2020.07.020 |
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author | Abenza-Abildúa, María José Novo-Aparicio, Susana Moreno-Zabaleta, Raúl Algarra-Lucas, Maria Carmen Rojo Moreno-Arcones, Blas Salvador-Maya, Miguel Ángel Navacerrada-Barrero, Francisco José Ojeda-Ruíz de Luna, Joaquín Pérez-López, Carlos Fraile-Vicente, José María Suárez-García, Inés Suarez-Gisbert, Eugenio Palacios-Castaño, Juan Antonio Ramirez-Prieto, María Teresa |
author_facet | Abenza-Abildúa, María José Novo-Aparicio, Susana Moreno-Zabaleta, Raúl Algarra-Lucas, Maria Carmen Rojo Moreno-Arcones, Blas Salvador-Maya, Miguel Ángel Navacerrada-Barrero, Francisco José Ojeda-Ruíz de Luna, Joaquín Pérez-López, Carlos Fraile-Vicente, José María Suárez-García, Inés Suarez-Gisbert, Eugenio Palacios-Castaño, Juan Antonio Ramirez-Prieto, María Teresa |
author_sort | Abenza-Abildúa, María José |
collection | PubMed |
description | Concerning the letter by Moriguchi et al., we describe our experience with a case of encephalopathy with and atypical damage on magnetic resonance imaging (MRI) in a patient with severe infection due to the SARS-CoV2 virus. A 56-year-old woman, without previous pathologies, developed cough, fever, and respiratory failure for five days, after returning from a 6-day trip to Venice. Chest radiography shows a large bilateral interstitial infiltrate. In the first 24 hours, she was admitted to the Intensive Care Unit (ICU) for severe respiratory failure and positive protein chain reaction-PCR in nasal exudate. She needed intubation for ten days. In the first 48 hours outside the ICU, she developed an acute confusional syndrome (hyperactive delirium). Neurological examination showed temporal-spatial disorientation and incoherent fluent speech. An electroencephalogram (EEG) showed generalized hypovoltaic activity. Cranial magnetic resonance imaging showed a bilateral and symmetrical increase in the supratentorial white matter's signal intensity, with a discrete thickening of both temporal lobes, with a slight increase in signal intensity and a sequence of normal diffusion. The lumbar puncture showed no changes (glucose 71 mg/dL, protein 30 mg/dL, 1 leukocyte). Within 72 hours of starting symptoms, she was neurologically asymptomatic. Our final diagnosis was an inflammatory encephalopathy related to a SARS-CoV2 infection. |
format | Online Article Text |
id | pubmed-7378010 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | The Author(s). Published by Elsevier Ltd on behalf of International Society for Infectious Diseases. |
record_format | MEDLINE/PubMed |
spelling | pubmed-73780102020-07-24 Encephalopathy in severe SARS-CoV2 infection: Inflammatory or infectious? Abenza-Abildúa, María José Novo-Aparicio, Susana Moreno-Zabaleta, Raúl Algarra-Lucas, Maria Carmen Rojo Moreno-Arcones, Blas Salvador-Maya, Miguel Ángel Navacerrada-Barrero, Francisco José Ojeda-Ruíz de Luna, Joaquín Pérez-López, Carlos Fraile-Vicente, José María Suárez-García, Inés Suarez-Gisbert, Eugenio Palacios-Castaño, Juan Antonio Ramirez-Prieto, María Teresa Int J Infect Dis Medical Imagery Concerning the letter by Moriguchi et al., we describe our experience with a case of encephalopathy with and atypical damage on magnetic resonance imaging (MRI) in a patient with severe infection due to the SARS-CoV2 virus. A 56-year-old woman, without previous pathologies, developed cough, fever, and respiratory failure for five days, after returning from a 6-day trip to Venice. Chest radiography shows a large bilateral interstitial infiltrate. In the first 24 hours, she was admitted to the Intensive Care Unit (ICU) for severe respiratory failure and positive protein chain reaction-PCR in nasal exudate. She needed intubation for ten days. In the first 48 hours outside the ICU, she developed an acute confusional syndrome (hyperactive delirium). Neurological examination showed temporal-spatial disorientation and incoherent fluent speech. An electroencephalogram (EEG) showed generalized hypovoltaic activity. Cranial magnetic resonance imaging showed a bilateral and symmetrical increase in the supratentorial white matter's signal intensity, with a discrete thickening of both temporal lobes, with a slight increase in signal intensity and a sequence of normal diffusion. The lumbar puncture showed no changes (glucose 71 mg/dL, protein 30 mg/dL, 1 leukocyte). Within 72 hours of starting symptoms, she was neurologically asymptomatic. Our final diagnosis was an inflammatory encephalopathy related to a SARS-CoV2 infection. The Author(s). Published by Elsevier Ltd on behalf of International Society for Infectious Diseases. 2020-09 2020-07-24 /pmc/articles/PMC7378010/ /pubmed/32712426 http://dx.doi.org/10.1016/j.ijid.2020.07.020 Text en © 2020 The Author(s) Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active. |
spellingShingle | Medical Imagery Abenza-Abildúa, María José Novo-Aparicio, Susana Moreno-Zabaleta, Raúl Algarra-Lucas, Maria Carmen Rojo Moreno-Arcones, Blas Salvador-Maya, Miguel Ángel Navacerrada-Barrero, Francisco José Ojeda-Ruíz de Luna, Joaquín Pérez-López, Carlos Fraile-Vicente, José María Suárez-García, Inés Suarez-Gisbert, Eugenio Palacios-Castaño, Juan Antonio Ramirez-Prieto, María Teresa Encephalopathy in severe SARS-CoV2 infection: Inflammatory or infectious? |
title | Encephalopathy in severe SARS-CoV2 infection: Inflammatory or infectious? |
title_full | Encephalopathy in severe SARS-CoV2 infection: Inflammatory or infectious? |
title_fullStr | Encephalopathy in severe SARS-CoV2 infection: Inflammatory or infectious? |
title_full_unstemmed | Encephalopathy in severe SARS-CoV2 infection: Inflammatory or infectious? |
title_short | Encephalopathy in severe SARS-CoV2 infection: Inflammatory or infectious? |
title_sort | encephalopathy in severe sars-cov2 infection: inflammatory or infectious? |
topic | Medical Imagery |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7378010/ https://www.ncbi.nlm.nih.gov/pubmed/32712426 http://dx.doi.org/10.1016/j.ijid.2020.07.020 |
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