Soluble Klotho, a biomarker and therapeutic strategy to reduce bronchopulmonary dysplasia and pulmonary hypertension in preterm infants

Preterm infants with bronchopulmonary dysplasia (BPD) and pulmonary hypertension (PH) have accelerated lung aging and poor long-term outcomes. Klotho is an antiaging protein that modulates oxidative stress, angiogenesis and fibrosis. Here we test the hypothesis that decreased cord Klotho levels in p...

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Detalles Bibliográficos
Autores principales: Batlahally, Sunil, Franklin, Andrew, Damianos, Andreas, Huang, Jian, Chen, Pingping, Sharma, Mayank, Duara, Joanne, Keerthy, Divya, Zambrano, Ronald, Shehadeh, Lina A., Martinez, Eliana C., DeFreitas, Marissa J., Kulandavelu, Shathiyah, Abitbol, Carolyn L., Freundlich, Michael, Kanashiro-Takeuchi, Rosemeire M., Schmidt, Augusto, Benny, Merline, Wu, Shu, Mestan, Karen K., Young, Karen C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7378054/
https://www.ncbi.nlm.nih.gov/pubmed/32704023
http://dx.doi.org/10.1038/s41598-020-69296-1

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