Comparing ultrafiltration and equilibrium dialysis to measure unbound plasma dolutegravir concentrations based on a design of experiment approach

Dolutegravir therapeutic drug monitoring (TDM) could be improved by measuring the unbound dolutegravir plasma concentration (Cu), particularly in patients experiencing virological failure or toxicity despite achieving appropriate DTG total plasma concentrations. Equilibrium dialysis (ED) is the gold...

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Detalles Bibliográficos
Autores principales: Metsu, David, Lanot, Thomas, Fraissinet, François, Concordet, Didier, Gayrard, Véronique, Averseng, Manon, Ressault, Alice, Martin-Blondel, Guillaume, Levade, Thierry, Février, Frédéric, Chatelut, Etienne, Delobel, Pierre, Gandia, Peggy
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7378073/
https://www.ncbi.nlm.nih.gov/pubmed/32703975
http://dx.doi.org/10.1038/s41598-020-69102-y

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