Prophylactic treatment with transdermal deferoxamine mitigates radiation-induced skin fibrosis

Radiation therapy can result in pathological fibrosis of healthy soft tissue. The iron chelator deferoxamine (DFO) has been shown to improve skin vascularization when injected into radiated tissue prior to fat grafting. Here, we evaluated whether topical DFO administration using a transdermal drug d...

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Detalles Bibliográficos
Autores principales: Shen, Abra H., Borrelli, Mimi R., Adem, Sandeep, Deleon, Nestor M. Diaz, Patel, Ronak A., Mascharak, Shamik, Yen, Sara J., Sun, Blake Y., Taylor, Walter L., Januszyk, Michael, Nguyen, Dung H., Momeni, Arash, Gurtner, Geoffrey C., Longaker, Michael T., Wan, Derrick C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7378074/
https://www.ncbi.nlm.nih.gov/pubmed/32704071
http://dx.doi.org/10.1038/s41598-020-69293-4

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