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Live imaging and functional changes of the inner ear in an animal model of Meniere’s disease

The symptoms of Meniere’s disease (MD) are generally considered to be related to endolymphatic hydrops (EH). There are many recent reports supporting the possibility that vasopressin (VP) is closely linked to the formation of EH in Meniere’s disease. Based on this, we developed a clinically relevant...

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Autores principales: Kakigi, Akinobu, Egami, Naoya, Uehara, Natsumi, Fujita, Takeshi, Nibu, Ken-ichi, Yamashita, Shinji, Yamasoba, Tatsuya
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7378199/
https://www.ncbi.nlm.nih.gov/pubmed/32704101
http://dx.doi.org/10.1038/s41598-020-68352-0
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author Kakigi, Akinobu
Egami, Naoya
Uehara, Natsumi
Fujita, Takeshi
Nibu, Ken-ichi
Yamashita, Shinji
Yamasoba, Tatsuya
author_facet Kakigi, Akinobu
Egami, Naoya
Uehara, Natsumi
Fujita, Takeshi
Nibu, Ken-ichi
Yamashita, Shinji
Yamasoba, Tatsuya
author_sort Kakigi, Akinobu
collection PubMed
description The symptoms of Meniere’s disease (MD) are generally considered to be related to endolymphatic hydrops (EH). There are many recent reports supporting the possibility that vasopressin (VP) is closely linked to the formation of EH in Meniere’s disease. Based on this, we developed a clinically relevant animal model of Meniere’s disease in which a VP type 2 receptor agonist was administered after electrocauterization of the endolymphatic sac. We report live imaging of the internal structure, and functional changes of the inner ear after electrocauterization of the endolymphatic sac and administration of a VP type 2 receptor agonist. In this model, the development of EH was visualized in vivo using optical coherence tomography, there was no rupture of Reissner’s membrane, and low-tone hearing loss and vertiginous attacks were observed. This study suggested that acute attacks are caused by the abrupt development of EH. This is the first report of live imaging of the development of EH induced by the administration of a VP type 2 receptor agonist.
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spelling pubmed-73781992020-07-24 Live imaging and functional changes of the inner ear in an animal model of Meniere’s disease Kakigi, Akinobu Egami, Naoya Uehara, Natsumi Fujita, Takeshi Nibu, Ken-ichi Yamashita, Shinji Yamasoba, Tatsuya Sci Rep Article The symptoms of Meniere’s disease (MD) are generally considered to be related to endolymphatic hydrops (EH). There are many recent reports supporting the possibility that vasopressin (VP) is closely linked to the formation of EH in Meniere’s disease. Based on this, we developed a clinically relevant animal model of Meniere’s disease in which a VP type 2 receptor agonist was administered after electrocauterization of the endolymphatic sac. We report live imaging of the internal structure, and functional changes of the inner ear after electrocauterization of the endolymphatic sac and administration of a VP type 2 receptor agonist. In this model, the development of EH was visualized in vivo using optical coherence tomography, there was no rupture of Reissner’s membrane, and low-tone hearing loss and vertiginous attacks were observed. This study suggested that acute attacks are caused by the abrupt development of EH. This is the first report of live imaging of the development of EH induced by the administration of a VP type 2 receptor agonist. Nature Publishing Group UK 2020-07-23 /pmc/articles/PMC7378199/ /pubmed/32704101 http://dx.doi.org/10.1038/s41598-020-68352-0 Text en © The Author(s) 2020 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
Kakigi, Akinobu
Egami, Naoya
Uehara, Natsumi
Fujita, Takeshi
Nibu, Ken-ichi
Yamashita, Shinji
Yamasoba, Tatsuya
Live imaging and functional changes of the inner ear in an animal model of Meniere’s disease
title Live imaging and functional changes of the inner ear in an animal model of Meniere’s disease
title_full Live imaging and functional changes of the inner ear in an animal model of Meniere’s disease
title_fullStr Live imaging and functional changes of the inner ear in an animal model of Meniere’s disease
title_full_unstemmed Live imaging and functional changes of the inner ear in an animal model of Meniere’s disease
title_short Live imaging and functional changes of the inner ear in an animal model of Meniere’s disease
title_sort live imaging and functional changes of the inner ear in an animal model of meniere’s disease
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7378199/
https://www.ncbi.nlm.nih.gov/pubmed/32704101
http://dx.doi.org/10.1038/s41598-020-68352-0
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