Analyzing kinetic signaling data for G-protein-coupled receptors

In classical pharmacology, bioassay data are fit to general equations (e.g. the dose response equation) to determine empirical drug parameters (e.g. EC(50) and E(max)), which are then used to calculate chemical parameters such as affinity and efficacy. Here we used a similar approach for kinetic, ti...

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Detalles Bibliográficos
Autores principales: Hoare, Sam R. J., Tewson, Paul H., Quinn, Anne Marie, Hughes, Thomas E., Bridge, Lloyd J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7378232/
https://www.ncbi.nlm.nih.gov/pubmed/32704081
http://dx.doi.org/10.1038/s41598-020-67844-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7378232/
https://www.ncbi.nlm.nih.gov/pubmed/32704081
http://dx.doi.org/10.1038/s41598-020-67844-3

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