Targeting adhesion to the vascular niche to improve therapy for acute myeloid leukemia

Niche hijack by malignant cells is considered to be a prominent cause of disease relapse. Barbier and colleagues uncover (E)-selectin as a novel mediator of malignant cell survival and regeneration which, upon blockade, has the potential to significantly improve therapeutic outcomes.

Detalles Bibliográficos
Autores principales: Haltalli, Myriam L. R., Lo Celso, Cristina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Comment
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7378234/
https://www.ncbi.nlm.nih.gov/pubmed/32703951
http://dx.doi.org/10.1038/s41467-020-17594-7
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author Haltalli, Myriam L. R.
Lo Celso, Cristina
author_facet Haltalli, Myriam L. R.
Lo Celso, Cristina
author_sort Haltalli, Myriam L. R.
collection PubMed
description Niche hijack by malignant cells is considered to be a prominent cause of disease relapse. Barbier and colleagues uncover (E)-selectin as a novel mediator of malignant cell survival and regeneration which, upon blockade, has the potential to significantly improve therapeutic outcomes.
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spelling pubmed-73782342020-07-28 Targeting adhesion to the vascular niche to improve therapy for acute myeloid leukemia Haltalli, Myriam L. R. Lo Celso, Cristina Nat Commun Comment Niche hijack by malignant cells is considered to be a prominent cause of disease relapse. Barbier and colleagues uncover (E)-selectin as a novel mediator of malignant cell survival and regeneration which, upon blockade, has the potential to significantly improve therapeutic outcomes. Nature Publishing Group UK 2020-07-23 /pmc/articles/PMC7378234/ /pubmed/32703951 http://dx.doi.org/10.1038/s41467-020-17594-7 Text en © The Author(s) 2020 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Comment
Haltalli, Myriam L. R.
Lo Celso, Cristina
Targeting adhesion to the vascular niche to improve therapy for acute myeloid leukemia
title Targeting adhesion to the vascular niche to improve therapy for acute myeloid leukemia
title_full Targeting adhesion to the vascular niche to improve therapy for acute myeloid leukemia
title_fullStr Targeting adhesion to the vascular niche to improve therapy for acute myeloid leukemia
title_full_unstemmed Targeting adhesion to the vascular niche to improve therapy for acute myeloid leukemia
title_short Targeting adhesion to the vascular niche to improve therapy for acute myeloid leukemia
title_sort targeting adhesion to the vascular niche to improve therapy for acute myeloid leukemia
topic Comment
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7378234/
https://www.ncbi.nlm.nih.gov/pubmed/32703951
http://dx.doi.org/10.1038/s41467-020-17594-7
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