Nuclear export of chimeric mRNAs depends on an lncRNA-triggered autoregulatory loop in blood malignancies

Aberrant chromosomal translocations leading to tumorigenesis have been ascribed to the heterogeneously oncogenic functions. However, how fusion transcripts exporting remains to be declared. Here, we showed that the nuclear speckle-specific long noncoding RNA MALAT1 controls chimeric mRNA export proc...

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Detalles Bibliográficos
Autores principales: Chen, Zhen-Hua, Chen, Tian-Qi, Zeng, Zhan-Cheng, Wang, Dan, Han, Cai, Sun, Yu-Meng, Huang, Wei, Sun, Lin-Yu, Fang, Ke, Chen, Yue-Qin, Luo, Xue-Qun, Wang, Wen-Tao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7378249/
https://www.ncbi.nlm.nih.gov/pubmed/32703936
http://dx.doi.org/10.1038/s41419-020-02795-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7378249/
https://www.ncbi.nlm.nih.gov/pubmed/32703936
http://dx.doi.org/10.1038/s41419-020-02795-1

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