Comparative evaluation of itaconate and its derivatives reveals divergent inflammasome and type I interferon regulation in macrophages

Upon activation, macrophages undergo extensive metabolic rewiring(1,2). Production of itaconate through the inducible enzyme IRG1 is a key hallmark of this process(3). Itaconate inhibits succinate dehydrogenase (SDH)(4,5), has electrophilic properties(6), and is associated with a change in cytokine...

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Detalles Bibliográficos
Autores principales: Swain, Amanda, Bambouskova, Monika, Kim, Hyeryun, Andhey, Prabhakar Sairam, Duncan, Dustin, Auclair, Karine, Chubukov, Victor, Simons, Donald M., Roddy, Thomas P., Stewart, Kelly M., Artyomov, Maxim N.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7378276/
https://www.ncbi.nlm.nih.gov/pubmed/32694786
http://dx.doi.org/10.1038/s42255-020-0210-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7378276/
https://www.ncbi.nlm.nih.gov/pubmed/32694786
http://dx.doi.org/10.1038/s42255-020-0210-0

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