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Comparative evaluation of itaconate and its derivatives reveals divergent inflammasome and type I interferon regulation in macrophages
Upon activation, macrophages undergo extensive metabolic rewiring(1,2). Production of itaconate through the inducible enzyme IRG1 is a key hallmark of this process(3). Itaconate inhibits succinate dehydrogenase (SDH)(4,5), has electrophilic properties(6), and is associated with a change in cytokine...
| Autores principales: | , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
2020
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7378276/ https://www.ncbi.nlm.nih.gov/pubmed/32694786 http://dx.doi.org/10.1038/s42255-020-0210-0 |