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Interaction of the Factor H Family Proteins FHR-1 and FHR-5 With DNA and Dead Cells: Implications for the Regulation of Complement Activation and Opsonization

Complement plays an essential role in the opsonophagocytic clearance of apoptotic/necrotic cells. Dysregulation of this process may lead to inflammatory and autoimmune diseases. Factor H (FH), a major soluble complement inhibitor, binds to dead cells and inhibits excessive complement activation on t...

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Detalles Bibliográficos
Autores principales:	Kárpáti, Éva, Papp, Alexandra, Schneider, Andrea E., Hajnal, Dávid, Cserhalmi, Marcell, Csincsi, Ádám I., Uzonyi, Barbara, Józsi, Mihály
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2020
Materias:	Immunology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7378360/ https://www.ncbi.nlm.nih.gov/pubmed/32765490 http://dx.doi.org/10.3389/fimmu.2020.01297

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