Cargando…

Use of Allopurinol to Mitigate 6-Mercaptopurine Associated Gastrointestinal Toxicity in Acute Lymphoblastic Leukemia

An essential component of acute lymphoblastic leukemia (ALL) therapy is the prolonged maintenance phase with daily 6-mercaptopurine (6-MP) as the cornerstone. While 6-MP is generally well-tolerated, some patients suffer from significant side effects such as gastrointestinal (GI) toxicity, including...

Descripción completa

Detalles Bibliográficos
Autores principales:	Conneely, Shannon E., Cooper, Stacy L., Rau, Rachel E.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2020
Materias:	Oncology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7378397/ https://www.ncbi.nlm.nih.gov/pubmed/32766146 http://dx.doi.org/10.3389/fonc.2020.01129

Ejemplares similares

Allopurinol use during pediatric acute lymphoblastic leukemia maintenance therapy safely corrects skewed 6-mercaptopurine metabolism, improving inadequate myelosuppression and reducing gastrointestinal toxicity
por: Cohen, Gordon, et al.
Publicado: (2020)

Allopurinol reverses mercaptopurine-induced hypoglycemia in patients with acute lymphoblastic leukemia
por: Zhang, Melissa, et al.
Publicado: (2019)

Adherence to 6-Mercaptopurine in children and adolescents with Acute Lymphoblastic Leukemia
por: Alsous, Mervat, et al.
Publicado: (2017)

2448 The effect of allopurinol on pediatric patients undergoing maintenance chemotherapy for acute lymphoblastic leukemia or lymphoblastic lymphoma
por: Bhuiyan, Mariam M., et al.
Publicado: (2018)

Murine Models of Acute Myeloid Leukemia
por: Kurtz, Kristen J., et al.
Publicado: (2022)

Screening of Novel Pharmacogenetic Candidates for Mercaptopurine-Induced Toxicity in Patients With Acute Lymphoblastic Leukemia
por: Cao, Minyuan, et al.
Publicado: (2020)

Corrigendum: Murine models of acute myeloid leukemia
por: Kurtz, Kristen J., et al.
Publicado: (2023)

ITPA, TPMT, and NUDT15 Genetic Polymorphisms Predict 6-Mercaptopurine Toxicity in Middle Eastern Children With Acute Lymphoblastic Leukemia
por: Moradveisi, Borhan, et al.
Publicado: (2019)

Variants in TPMT, ITPA, ABCC4 and ABCB1 Genes As Predictors of 6-mercaptopurine Induced Toxicity in Children with Acute Lymphoblastic Leukemia
por: Milosevic, Goran, et al.
Publicado: (2018)

Effects of TPMT, NUDT15, and ITPA Genetic Variants on 6-Mercaptopurine Toxicity for Pediatric Patients With Acute Lymphoblastic Leukemia in Yunnan of China
por: Mao, Xiaoyan, et al.
Publicado: (2021)

Severe recurrent nocturnal hypoglycemia during chemotherapy with 6-mercaptopurine in a child with acute lymphoblastic leukemia
por: Cho, Eun Mi, et al.
Publicado: (2018)

The influence of NUDT15 variants on 6-mercaptopurine-induced neutropenia in Vietnamese pediatric acute lymphoblastic leukemia
por: Nguyen, Mai-Lan, et al.
Publicado: (2023)

Genetic variants of genes involved in thiopurine metabolism pathway are associated with 6-mercaptopurine toxicity in pediatric acute lymphoblastic leukemia patients from Ethiopia
por: Ali, Awol Mekonnen, et al.
Publicado: (2023)

Childhood lymphoblastic leukaemia: sex difference in 6-mercaptopurine utilization.
por: Lilleyman, J. S., et al.
Publicado: (1984)

Preparation, Characterization, Pharmacokinetic, and Therapeutic Potential of Novel 6-Mercaptopurine-Loaded Oral Nanomedicines for Acute Lymphoblastic Leukemia
por: Zou, Yaru, et al.
Publicado: (2021)

TPMT*3C as a Predictor of 6-Mercaptopurine-Induced Myelotoxicity in Thai Children with Acute Lymphoblastic Leukemia
por: Jantararoungtong, Thawinee, et al.
Publicado: (2021)

Mercaptopurine/Methotrexate Maintenance Therapy of Childhood Acute Lymphoblastic Leukemia: Clinical Facts and Fiction
por: Schmiegelow, Kjeld, et al.
Publicado: (2014)

Is 6-thioguanine more appropriate than 6-mercaptopurine for children with acute lymphoblastic leukaemia?
por: Lennard, L., et al.
Publicado: (1993)

Optimal predictor for 6-mercaptopurine intolerance in Chinese children with acute lymphoblastic leukemia: NUDT15, TPMT, or ITPA genetic variants?
por: Zhou, Hong, et al.
Publicado: (2018)

An international retrospective study for tolerability of 6-mercaptopurine on NUDT15 bi-allelic variants in children with acute lymphoblastic leukemia
por: Tanaka, Yoichi, et al.
Publicado: (2021)

Prevalence of TPMT and ITPA gene polymorphisms and effect on mercaptopurine dosage in Chilean children with acute lymphoblastic leukemia
por: Farfan, Mauricio J, et al.
Publicado: (2014)

APEX1 Polymorphism and Mercaptopurine-Related Early Onset Neutropenia in Pediatric Acute Lymphoblastic Leukemia
por: Kim, Hyery, et al.
Publicado: (2018)

Current Use of Asparaginase in Acute Lymphoblastic Leukemia/Lymphoblastic Lymphoma
por: Maese, Luke, et al.
Publicado: (2022)

Toxicity evaluation of 6-mercaptopurine-Chitosan nanoparticles in rats
por: Govindappa, Prem Kumar, et al.
Publicado: (2020)

Two Brothers with Skewed Thiopurine Metabolism in Ulcerative Colitis Treated Successfully with Allopurinol and Mercaptopurine Dose Reduction
por: Hoentjen, Frank, et al.
Publicado: (2011)

Incidence and determinants of hematotoxicity in acute lymphoblastic leukemia children who received 6-mercaptopurine based maintenance therapy in Addis Ababa, Ethiopia
por: Ali, Awol Mekonnen, et al.
Publicado: (2023)

Combination treatment with 6-mercaptopurine and allopurinol in HepG2 and HEK293 cells – Effects on gene expression levels and thiopurine metabolism
por: Haglund, Sofie, et al.
Publicado: (2017)

Leukemia-Initiating Cells in T-Cell Acute Lymphoblastic Leukemia
por: Tan, Shi Hao, et al.
Publicado: (2017)

Adipocytes Provide Fatty Acids to Acute Lymphoblastic Leukemia Cells
por: Tucci, Jonathan, et al.
Publicado: (2021)

Effect of ITPA Polymorphism on Adverse Drug Reactions of 6-Mercaptopurine in Pediatric Patients with Acute Lymphoblastic Leukemia: A Systematic Review and Meta-Analysis
por: Lee, Yeonhong, et al.
Publicado: (2022)

SUPPRESSION OF ALLERGIC UVEITIS BY 6-MERCAPTOPURINE
por: Wirostko, E., et al.
Publicado: (1962)

The Effect of NUDT15, TPMT, APEX1, and ITPA Genetic Variations on Mercaptopurine Treatment of Pediatric Acute Lymphoblastic Leukemia
por: Lee, Jae Min, et al.
Publicado: (2021)

The effects of 6-mercaptopurine nucleotide derivatives on the growth and survival of 6-mercaptopurine-sensitive and -resistant cell culture lines.
por: Johnston, H. P., et al.
Publicado: (1985)

Star Allele-Based Haplotyping versus Gene-Wise Variant Burden Scoring for Predicting 6-Mercaptopurine Intolerance in Pediatric Acute Lymphoblastic Leukemia Patients
por: Park, Yoomi, et al.
Publicado: (2019)

The Inhibitory Effects of 6-Thioguanine and 6-Mercaptopurine on the USP2a Target Fatty Acid Synthase in Human Submaxillary Carcinoma Cells
por: Cheng, Chiao-Pei, et al.
Publicado: (2021)

Mechanistic mathematical modelling of mercaptopurine effects on cell cycle of human acute lymphoblastic leukaemia cells
por: Panetta, J C, et al.
Publicado: (2006)

Pancytopenia and Septic Infection Caused by Concurrent Use of Allopurinol and Mercaptopurine: A Case Report Illustrating the Importance of Clinical Pharmacist Consultation
por: Alhubaishi, Alaa A.
Publicado: (2019)

Asparagine Synthetase in Cancer: Beyond Acute Lymphoblastic Leukemia
por: Chiu, Martina, et al.
Publicado: (2020)

Crystal structures of five 6-mercaptopurine derivatives
por: Gomes, Lígia R., et al.
Publicado: (2016)

Oral Maintenance Chemotherapy with 6-Mercaptopurine and Methotrexate in Patients with Acute Myeloid Leukemia Ineligible for Transplantation
por: Choi, Yong Won, et al.
Publicado: (2015)

Cannot write session to /tmp/vufind_sessions/sess_o182bqifj3o58m4ovlmv13tg3t