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Elevated serum glycated albumin and glycated albumin : hemoglobin A(1c) ratio were associated with hippocampal atrophy in a general elderly population of Japanese: The Hisayama Study

AIMS/INTRODUCTION: To investigate the association of alternative glycemic measures – namely, serum glycated albumin (GA), hemoglobin A(1c) (HbA(1c)) and the GA : HbA(1c) ratio – with global brain and hippocampal atrophy in a general elderly Japanese population. MATERIALS AND METHODS: A total of 1,27...

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Autores principales: Ohara, Tomoyuki, Furuta, Yoshihiko, Hirabayashi, Naoki, Hata, Jun, Hirakawa, Yoichiro, Honda, Takanori, Yoshida, Daigo, Shibata, Mao, Kitazono, Takanari, Ninomiya, Toshiharu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7378434/
https://www.ncbi.nlm.nih.gov/pubmed/31999889
http://dx.doi.org/10.1111/jdi.13220
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author Ohara, Tomoyuki
Furuta, Yoshihiko
Hirabayashi, Naoki
Hata, Jun
Hirakawa, Yoichiro
Honda, Takanori
Yoshida, Daigo
Shibata, Mao
Kitazono, Takanari
Ninomiya, Toshiharu
author_facet Ohara, Tomoyuki
Furuta, Yoshihiko
Hirabayashi, Naoki
Hata, Jun
Hirakawa, Yoichiro
Honda, Takanori
Yoshida, Daigo
Shibata, Mao
Kitazono, Takanari
Ninomiya, Toshiharu
author_sort Ohara, Tomoyuki
collection PubMed
description AIMS/INTRODUCTION: To investigate the association of alternative glycemic measures – namely, serum glycated albumin (GA), hemoglobin A(1c) (HbA(1c)) and the GA : HbA(1c) ratio – with global brain and hippocampal atrophy in a general elderly Japanese population. MATERIALS AND METHODS: A total of 1,278 Japanese individuals aged ≥65 years in a community participated in brain magnetic resonance imaging scanning and screening examination of health status in 2012. We measured total brain volume (TBV), hippocampal volume (HV) and intracranial volume (ICV) using the data from the magnetic resonance imaging examination. The association of each glycemic measure with the ratios of TBV : ICV (an indicator of global brain atrophy) and HV : ICV (an indicator of hippocampal atrophy) was examined by analysis of covariance. RESULTS: The mean values of the TBV : ICV and HV : ICV ratios decreased significantly with elevating serum GA levels and GA : HbA(1c) ratio levels (all P for trend < 0.05), but not with higher HbA(1c) levels, after adjusting for age, sex, low education, systolic blood pressure, antihypertensive medication, diabetes mellitus, serum total cholesterol, electrocardiogram abnormalities, body mass index, smoking habits, alcohol drinking habits and regular exercise. These significant associations were still observed in the sensitivity analysis after excluding individuals with mild cognitive impairment and dementia. In addition, increased serum GA levels and the GA : HbA(1c) ratio levels, but not HbA(1c), were closely associated with lower mean values of the TBV : ICV and HV : ICV ratios, irrespective of the presence or absence of diabetes mellitus. CONCLUSIONS: The present study suggests that higher serum GA and higher GA : HbA(1c) ratio are significantly associated with global brain and hippocampal atrophy.
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spelling pubmed-73784342020-07-27 Elevated serum glycated albumin and glycated albumin : hemoglobin A(1c) ratio were associated with hippocampal atrophy in a general elderly population of Japanese: The Hisayama Study Ohara, Tomoyuki Furuta, Yoshihiko Hirabayashi, Naoki Hata, Jun Hirakawa, Yoichiro Honda, Takanori Yoshida, Daigo Shibata, Mao Kitazono, Takanari Ninomiya, Toshiharu J Diabetes Investig Articles AIMS/INTRODUCTION: To investigate the association of alternative glycemic measures – namely, serum glycated albumin (GA), hemoglobin A(1c) (HbA(1c)) and the GA : HbA(1c) ratio – with global brain and hippocampal atrophy in a general elderly Japanese population. MATERIALS AND METHODS: A total of 1,278 Japanese individuals aged ≥65 years in a community participated in brain magnetic resonance imaging scanning and screening examination of health status in 2012. We measured total brain volume (TBV), hippocampal volume (HV) and intracranial volume (ICV) using the data from the magnetic resonance imaging examination. The association of each glycemic measure with the ratios of TBV : ICV (an indicator of global brain atrophy) and HV : ICV (an indicator of hippocampal atrophy) was examined by analysis of covariance. RESULTS: The mean values of the TBV : ICV and HV : ICV ratios decreased significantly with elevating serum GA levels and GA : HbA(1c) ratio levels (all P for trend < 0.05), but not with higher HbA(1c) levels, after adjusting for age, sex, low education, systolic blood pressure, antihypertensive medication, diabetes mellitus, serum total cholesterol, electrocardiogram abnormalities, body mass index, smoking habits, alcohol drinking habits and regular exercise. These significant associations were still observed in the sensitivity analysis after excluding individuals with mild cognitive impairment and dementia. In addition, increased serum GA levels and the GA : HbA(1c) ratio levels, but not HbA(1c), were closely associated with lower mean values of the TBV : ICV and HV : ICV ratios, irrespective of the presence or absence of diabetes mellitus. CONCLUSIONS: The present study suggests that higher serum GA and higher GA : HbA(1c) ratio are significantly associated with global brain and hippocampal atrophy. John Wiley and Sons Inc. 2020-03-01 2020-07 /pmc/articles/PMC7378434/ /pubmed/31999889 http://dx.doi.org/10.1111/jdi.13220 Text en © 2020 The Authors. Journal of Diabetes Investigation published by Asian Association for the Study of Diabetes (AASD) and John Wiley & Sons Australia, Ltd This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.
spellingShingle Articles
Ohara, Tomoyuki
Furuta, Yoshihiko
Hirabayashi, Naoki
Hata, Jun
Hirakawa, Yoichiro
Honda, Takanori
Yoshida, Daigo
Shibata, Mao
Kitazono, Takanari
Ninomiya, Toshiharu
Elevated serum glycated albumin and glycated albumin : hemoglobin A(1c) ratio were associated with hippocampal atrophy in a general elderly population of Japanese: The Hisayama Study
title Elevated serum glycated albumin and glycated albumin : hemoglobin A(1c) ratio were associated with hippocampal atrophy in a general elderly population of Japanese: The Hisayama Study
title_full Elevated serum glycated albumin and glycated albumin : hemoglobin A(1c) ratio were associated with hippocampal atrophy in a general elderly population of Japanese: The Hisayama Study
title_fullStr Elevated serum glycated albumin and glycated albumin : hemoglobin A(1c) ratio were associated with hippocampal atrophy in a general elderly population of Japanese: The Hisayama Study
title_full_unstemmed Elevated serum glycated albumin and glycated albumin : hemoglobin A(1c) ratio were associated with hippocampal atrophy in a general elderly population of Japanese: The Hisayama Study
title_short Elevated serum glycated albumin and glycated albumin : hemoglobin A(1c) ratio were associated with hippocampal atrophy in a general elderly population of Japanese: The Hisayama Study
title_sort elevated serum glycated albumin and glycated albumin : hemoglobin a(1c) ratio were associated with hippocampal atrophy in a general elderly population of japanese: the hisayama study
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7378434/
https://www.ncbi.nlm.nih.gov/pubmed/31999889
http://dx.doi.org/10.1111/jdi.13220
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