Sars-CoV-2 in pregnancy: Why is it better than expected?

Since the outbreak of Coronavirus disease in December 2019, information specific to pregnancy remains limited and controversial. Based on data from previous reports, it has been noticed that contrary to prior pandemics such as SARS, MERS and H1N1 and although pregnancy is usually considered as a con...

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Autores principales: Ghi, Tullio, di Pasquo, Elvira, Mekinian, Arsene, Calza, Leonardo, Frusca, Tiziana
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier B.V. 2020
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7378463/
https://www.ncbi.nlm.nih.gov/pubmed/32739606
http://dx.doi.org/10.1016/j.ejogrb.2020.07.025
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author Ghi, Tullio
di Pasquo, Elvira
Mekinian, Arsene
Calza, Leonardo
Frusca, Tiziana
author_facet Ghi, Tullio
di Pasquo, Elvira
Mekinian, Arsene
Calza, Leonardo
Frusca, Tiziana
author_sort Ghi, Tullio
collection PubMed
description Since the outbreak of Coronavirus disease in December 2019, information specific to pregnancy remains limited and controversial. Based on data from previous reports, it has been noticed that contrary to prior pandemics such as SARS, MERS and H1N1 and although pregnancy is usually considered as a condition of high susceptibility to viral infections, new SARS-CoV2 infection seems to have a more benign clinical course when affecting pregnant women. We speculate that during pregnancy the physiological “silencing” of the Th1 pro-inflammatory response may blunt the cytokines storm which is thought to play a key-role in the pathogenesis of the severe complications of Covid-19.
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spelling pubmed-73784632020-07-24 Sars-CoV-2 in pregnancy: Why is it better than expected? Ghi, Tullio di Pasquo, Elvira Mekinian, Arsene Calza, Leonardo Frusca, Tiziana Eur J Obstet Gynecol Reprod Biol Review Article Since the outbreak of Coronavirus disease in December 2019, information specific to pregnancy remains limited and controversial. Based on data from previous reports, it has been noticed that contrary to prior pandemics such as SARS, MERS and H1N1 and although pregnancy is usually considered as a condition of high susceptibility to viral infections, new SARS-CoV2 infection seems to have a more benign clinical course when affecting pregnant women. We speculate that during pregnancy the physiological “silencing” of the Th1 pro-inflammatory response may blunt the cytokines storm which is thought to play a key-role in the pathogenesis of the severe complications of Covid-19. Elsevier B.V. 2020-09 2020-07-24 /pmc/articles/PMC7378463/ /pubmed/32739606 http://dx.doi.org/10.1016/j.ejogrb.2020.07.025 Text en © 2020 Elsevier B.V. All rights reserved. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Review Article
Ghi, Tullio
di Pasquo, Elvira
Mekinian, Arsene
Calza, Leonardo
Frusca, Tiziana
Sars-CoV-2 in pregnancy: Why is it better than expected?
title Sars-CoV-2 in pregnancy: Why is it better than expected?
title_full Sars-CoV-2 in pregnancy: Why is it better than expected?
title_fullStr Sars-CoV-2 in pregnancy: Why is it better than expected?
title_full_unstemmed Sars-CoV-2 in pregnancy: Why is it better than expected?
title_short Sars-CoV-2 in pregnancy: Why is it better than expected?
title_sort sars-cov-2 in pregnancy: why is it better than expected?
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7378463/
https://www.ncbi.nlm.nih.gov/pubmed/32739606
http://dx.doi.org/10.1016/j.ejogrb.2020.07.025
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