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PERK-Mediated Suppression of microRNAs by Sildenafil Improves Mitochondrial Dysfunction in Heart Failure

Oxidative/nitrosative stress is a major trigger of cardiac dysfunction, involving the unfolded protein response and mitochondrial dysfunction. Activation of nitric oxide-cyclic guanosine monophosphate-protein kinase G signaling by sildenafil improves cardiac mal-remodeling during pressure-overload-i...

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Detalles Bibliográficos
Autores principales:	Shimizu, Takashi, Taguchi, Akashi, Higashijima, Yoshiki, Takubo, Naoko, Kanki, Yasuharu, Urade, Yoshihiro, Wada, Youichiro
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7378464/ https://www.ncbi.nlm.nih.gov/pubmed/32768667 http://dx.doi.org/10.1016/j.isci.2020.101410

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