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Neoadjuvant Four-Drug Combination Therapy for NSCLC With EGFR Mutation Avoiding Total Pneumonectomy
We report a case of successful neoadjuvant four-drug combination therapy to avoid total pneumonectomy. A 33-year-old male patient was diagnosed with locally advanced non-squamous NSCLC harboring EGFR mutation in the left lower lobe. The patient experienced significant clinical downstaging after two...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7378529/ https://www.ncbi.nlm.nih.gov/pubmed/32766151 http://dx.doi.org/10.3389/fonc.2020.01145 |
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author | Li, Jingpei Xu, Ke Cai, Weipeng Zhang, Yalei Zeng, Xin Cui, Fei Hao, Zhexue Liu, Jun He, Jianxing |
author_facet | Li, Jingpei Xu, Ke Cai, Weipeng Zhang, Yalei Zeng, Xin Cui, Fei Hao, Zhexue Liu, Jun He, Jianxing |
author_sort | Li, Jingpei |
collection | PubMed |
description | We report a case of successful neoadjuvant four-drug combination therapy to avoid total pneumonectomy. A 33-year-old male patient was diagnosed with locally advanced non-squamous NSCLC harboring EGFR mutation in the left lower lobe. The patient experienced significant clinical downstaging after two cycles of neoadjuvant therapy, including icotinib, carboplatin, pemetrexed, and bevacizumab. He underwent a successful lobectomy avoiding pneumonectomy. The patient showed no recurrence in the follow-up of a chest computed tomographic scan, which is 17 months after surgery. The promising results of this neoadjuvant combination therapy provided a novel therapeutic option for patients with locally advanced EGFR-mutated NSCLC facing total pneumonectomy. |
format | Online Article Text |
id | pubmed-7378529 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-73785292020-08-05 Neoadjuvant Four-Drug Combination Therapy for NSCLC With EGFR Mutation Avoiding Total Pneumonectomy Li, Jingpei Xu, Ke Cai, Weipeng Zhang, Yalei Zeng, Xin Cui, Fei Hao, Zhexue Liu, Jun He, Jianxing Front Oncol Oncology We report a case of successful neoadjuvant four-drug combination therapy to avoid total pneumonectomy. A 33-year-old male patient was diagnosed with locally advanced non-squamous NSCLC harboring EGFR mutation in the left lower lobe. The patient experienced significant clinical downstaging after two cycles of neoadjuvant therapy, including icotinib, carboplatin, pemetrexed, and bevacizumab. He underwent a successful lobectomy avoiding pneumonectomy. The patient showed no recurrence in the follow-up of a chest computed tomographic scan, which is 17 months after surgery. The promising results of this neoadjuvant combination therapy provided a novel therapeutic option for patients with locally advanced EGFR-mutated NSCLC facing total pneumonectomy. Frontiers Media S.A. 2020-07-16 /pmc/articles/PMC7378529/ /pubmed/32766151 http://dx.doi.org/10.3389/fonc.2020.01145 Text en Copyright © 2020 Li, Xu, Cai, Zhang, Zeng, Cui, Hao, Liu and He. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Oncology Li, Jingpei Xu, Ke Cai, Weipeng Zhang, Yalei Zeng, Xin Cui, Fei Hao, Zhexue Liu, Jun He, Jianxing Neoadjuvant Four-Drug Combination Therapy for NSCLC With EGFR Mutation Avoiding Total Pneumonectomy |
title | Neoadjuvant Four-Drug Combination Therapy for NSCLC With EGFR Mutation Avoiding Total Pneumonectomy |
title_full | Neoadjuvant Four-Drug Combination Therapy for NSCLC With EGFR Mutation Avoiding Total Pneumonectomy |
title_fullStr | Neoadjuvant Four-Drug Combination Therapy for NSCLC With EGFR Mutation Avoiding Total Pneumonectomy |
title_full_unstemmed | Neoadjuvant Four-Drug Combination Therapy for NSCLC With EGFR Mutation Avoiding Total Pneumonectomy |
title_short | Neoadjuvant Four-Drug Combination Therapy for NSCLC With EGFR Mutation Avoiding Total Pneumonectomy |
title_sort | neoadjuvant four-drug combination therapy for nsclc with egfr mutation avoiding total pneumonectomy |
topic | Oncology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7378529/ https://www.ncbi.nlm.nih.gov/pubmed/32766151 http://dx.doi.org/10.3389/fonc.2020.01145 |
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