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Neoadjuvant Four-Drug Combination Therapy for NSCLC With EGFR Mutation Avoiding Total Pneumonectomy

We report a case of successful neoadjuvant four-drug combination therapy to avoid total pneumonectomy. A 33-year-old male patient was diagnosed with locally advanced non-squamous NSCLC harboring EGFR mutation in the left lower lobe. The patient experienced significant clinical downstaging after two...

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Autores principales: Li, Jingpei, Xu, Ke, Cai, Weipeng, Zhang, Yalei, Zeng, Xin, Cui, Fei, Hao, Zhexue, Liu, Jun, He, Jianxing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7378529/
https://www.ncbi.nlm.nih.gov/pubmed/32766151
http://dx.doi.org/10.3389/fonc.2020.01145
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author Li, Jingpei
Xu, Ke
Cai, Weipeng
Zhang, Yalei
Zeng, Xin
Cui, Fei
Hao, Zhexue
Liu, Jun
He, Jianxing
author_facet Li, Jingpei
Xu, Ke
Cai, Weipeng
Zhang, Yalei
Zeng, Xin
Cui, Fei
Hao, Zhexue
Liu, Jun
He, Jianxing
author_sort Li, Jingpei
collection PubMed
description We report a case of successful neoadjuvant four-drug combination therapy to avoid total pneumonectomy. A 33-year-old male patient was diagnosed with locally advanced non-squamous NSCLC harboring EGFR mutation in the left lower lobe. The patient experienced significant clinical downstaging after two cycles of neoadjuvant therapy, including icotinib, carboplatin, pemetrexed, and bevacizumab. He underwent a successful lobectomy avoiding pneumonectomy. The patient showed no recurrence in the follow-up of a chest computed tomographic scan, which is 17 months after surgery. The promising results of this neoadjuvant combination therapy provided a novel therapeutic option for patients with locally advanced EGFR-mutated NSCLC facing total pneumonectomy.
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spelling pubmed-73785292020-08-05 Neoadjuvant Four-Drug Combination Therapy for NSCLC With EGFR Mutation Avoiding Total Pneumonectomy Li, Jingpei Xu, Ke Cai, Weipeng Zhang, Yalei Zeng, Xin Cui, Fei Hao, Zhexue Liu, Jun He, Jianxing Front Oncol Oncology We report a case of successful neoadjuvant four-drug combination therapy to avoid total pneumonectomy. A 33-year-old male patient was diagnosed with locally advanced non-squamous NSCLC harboring EGFR mutation in the left lower lobe. The patient experienced significant clinical downstaging after two cycles of neoadjuvant therapy, including icotinib, carboplatin, pemetrexed, and bevacizumab. He underwent a successful lobectomy avoiding pneumonectomy. The patient showed no recurrence in the follow-up of a chest computed tomographic scan, which is 17 months after surgery. The promising results of this neoadjuvant combination therapy provided a novel therapeutic option for patients with locally advanced EGFR-mutated NSCLC facing total pneumonectomy. Frontiers Media S.A. 2020-07-16 /pmc/articles/PMC7378529/ /pubmed/32766151 http://dx.doi.org/10.3389/fonc.2020.01145 Text en Copyright © 2020 Li, Xu, Cai, Zhang, Zeng, Cui, Hao, Liu and He. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Oncology
Li, Jingpei
Xu, Ke
Cai, Weipeng
Zhang, Yalei
Zeng, Xin
Cui, Fei
Hao, Zhexue
Liu, Jun
He, Jianxing
Neoadjuvant Four-Drug Combination Therapy for NSCLC With EGFR Mutation Avoiding Total Pneumonectomy
title Neoadjuvant Four-Drug Combination Therapy for NSCLC With EGFR Mutation Avoiding Total Pneumonectomy
title_full Neoadjuvant Four-Drug Combination Therapy for NSCLC With EGFR Mutation Avoiding Total Pneumonectomy
title_fullStr Neoadjuvant Four-Drug Combination Therapy for NSCLC With EGFR Mutation Avoiding Total Pneumonectomy
title_full_unstemmed Neoadjuvant Four-Drug Combination Therapy for NSCLC With EGFR Mutation Avoiding Total Pneumonectomy
title_short Neoadjuvant Four-Drug Combination Therapy for NSCLC With EGFR Mutation Avoiding Total Pneumonectomy
title_sort neoadjuvant four-drug combination therapy for nsclc with egfr mutation avoiding total pneumonectomy
topic Oncology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7378529/
https://www.ncbi.nlm.nih.gov/pubmed/32766151
http://dx.doi.org/10.3389/fonc.2020.01145
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