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Circulating Tumor Cells in Metastatic Breast Cancer: From Genome Instability to Metastasis
The emergence of clinical resistance in repeatedly treated cancers extends from the primary tumor's capability to exploit genome instability to adapt, escape, and progress. Triple negative breast cancer serves as a good example of such a response demonstrating poor clinical outcome due to a hig...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2020
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7378584/ https://www.ncbi.nlm.nih.gov/pubmed/32766277 http://dx.doi.org/10.3389/fmolb.2020.00134 |
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author | Ivanova, Ekaterina Ward, Ambber Wiegmans, Adrian P. Richard, Derek John |
author_facet | Ivanova, Ekaterina Ward, Ambber Wiegmans, Adrian P. Richard, Derek John |
author_sort | Ivanova, Ekaterina |
collection | PubMed |
description | The emergence of clinical resistance in repeatedly treated cancers extends from the primary tumor's capability to exploit genome instability to adapt, escape, and progress. Triple negative breast cancer serves as a good example of such a response demonstrating poor clinical outcome due to a high rate of cellular heterogeneity resulting in metastatic relapse. The capability to effectively track the emergence of therapeutic resistance in real-time and adapt the clinical response is the holy grail for precision medicine and has yet to be realized. In this review we present liquid biopsy using CTCs and ctDNA as a potential replacement and/or addition to the current diagnostic tests to deliver personalized therapies to patients with advanced breast cancer. We outline current uses of liquid biopsy in the metastatic breast cancer setting and discuss their limitations. In addition, we provide a detailed overview of common genome instability events in patients with metastatic breast cancer and how these can be tracked using liquid biopsy. |
format | Online Article Text |
id | pubmed-7378584 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-73785842020-08-05 Circulating Tumor Cells in Metastatic Breast Cancer: From Genome Instability to Metastasis Ivanova, Ekaterina Ward, Ambber Wiegmans, Adrian P. Richard, Derek John Front Mol Biosci Molecular Biosciences The emergence of clinical resistance in repeatedly treated cancers extends from the primary tumor's capability to exploit genome instability to adapt, escape, and progress. Triple negative breast cancer serves as a good example of such a response demonstrating poor clinical outcome due to a high rate of cellular heterogeneity resulting in metastatic relapse. The capability to effectively track the emergence of therapeutic resistance in real-time and adapt the clinical response is the holy grail for precision medicine and has yet to be realized. In this review we present liquid biopsy using CTCs and ctDNA as a potential replacement and/or addition to the current diagnostic tests to deliver personalized therapies to patients with advanced breast cancer. We outline current uses of liquid biopsy in the metastatic breast cancer setting and discuss their limitations. In addition, we provide a detailed overview of common genome instability events in patients with metastatic breast cancer and how these can be tracked using liquid biopsy. Frontiers Media S.A. 2020-07-16 /pmc/articles/PMC7378584/ /pubmed/32766277 http://dx.doi.org/10.3389/fmolb.2020.00134 Text en Copyright © 2020 Ivanova, Ward, Wiegmans and Richard. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Molecular Biosciences Ivanova, Ekaterina Ward, Ambber Wiegmans, Adrian P. Richard, Derek John Circulating Tumor Cells in Metastatic Breast Cancer: From Genome Instability to Metastasis |
title | Circulating Tumor Cells in Metastatic Breast Cancer: From Genome Instability to Metastasis |
title_full | Circulating Tumor Cells in Metastatic Breast Cancer: From Genome Instability to Metastasis |
title_fullStr | Circulating Tumor Cells in Metastatic Breast Cancer: From Genome Instability to Metastasis |
title_full_unstemmed | Circulating Tumor Cells in Metastatic Breast Cancer: From Genome Instability to Metastasis |
title_short | Circulating Tumor Cells in Metastatic Breast Cancer: From Genome Instability to Metastasis |
title_sort | circulating tumor cells in metastatic breast cancer: from genome instability to metastasis |
topic | Molecular Biosciences |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7378584/ https://www.ncbi.nlm.nih.gov/pubmed/32766277 http://dx.doi.org/10.3389/fmolb.2020.00134 |
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