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Development of MicroRNAs as Potential Therapeutics against Cancer

MicroRNAs (miRNAs) are small noncoding RNAs that function at the posttranscriptional level in the cellular regulation process. miRNA expression exerts vital effects on cell growth such as cell proliferation and survival. In cancers, miRNAs have been shown to initiate carcinogenesis, where overexpres...

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Detalles Bibliográficos
Autores principales: Abd-Aziz, Noraini, Kamaruzman, Nur Izyani, Poh, Chit Laa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7378626/
https://www.ncbi.nlm.nih.gov/pubmed/32733559
http://dx.doi.org/10.1155/2020/8029721
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author Abd-Aziz, Noraini
Kamaruzman, Nur Izyani
Poh, Chit Laa
author_facet Abd-Aziz, Noraini
Kamaruzman, Nur Izyani
Poh, Chit Laa
author_sort Abd-Aziz, Noraini
collection PubMed
description MicroRNAs (miRNAs) are small noncoding RNAs that function at the posttranscriptional level in the cellular regulation process. miRNA expression exerts vital effects on cell growth such as cell proliferation and survival. In cancers, miRNAs have been shown to initiate carcinogenesis, where overexpression of oncogenic miRNAs (oncomiRs) or reduced expression of tumor suppressor miRNAs has been reported. In this review, we discuss the involvement of miRNAs in tumorigenesis, the role of synthetic miRNAs as either mimics or antagomirs to overcome cancer growth, miRNA delivery, and approaches to enhance their therapeutic potentials.
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spelling pubmed-73786262020-07-29 Development of MicroRNAs as Potential Therapeutics against Cancer Abd-Aziz, Noraini Kamaruzman, Nur Izyani Poh, Chit Laa J Oncol Review Article MicroRNAs (miRNAs) are small noncoding RNAs that function at the posttranscriptional level in the cellular regulation process. miRNA expression exerts vital effects on cell growth such as cell proliferation and survival. In cancers, miRNAs have been shown to initiate carcinogenesis, where overexpression of oncogenic miRNAs (oncomiRs) or reduced expression of tumor suppressor miRNAs has been reported. In this review, we discuss the involvement of miRNAs in tumorigenesis, the role of synthetic miRNAs as either mimics or antagomirs to overcome cancer growth, miRNA delivery, and approaches to enhance their therapeutic potentials. Hindawi 2020-07-15 /pmc/articles/PMC7378626/ /pubmed/32733559 http://dx.doi.org/10.1155/2020/8029721 Text en Copyright © 2020 Noraini Abd-Aziz et al. http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Abd-Aziz, Noraini
Kamaruzman, Nur Izyani
Poh, Chit Laa
Development of MicroRNAs as Potential Therapeutics against Cancer
title Development of MicroRNAs as Potential Therapeutics against Cancer
title_full Development of MicroRNAs as Potential Therapeutics against Cancer
title_fullStr Development of MicroRNAs as Potential Therapeutics against Cancer
title_full_unstemmed Development of MicroRNAs as Potential Therapeutics against Cancer
title_short Development of MicroRNAs as Potential Therapeutics against Cancer
title_sort development of micrornas as potential therapeutics against cancer
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7378626/
https://www.ncbi.nlm.nih.gov/pubmed/32733559
http://dx.doi.org/10.1155/2020/8029721
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