In-Situ X-ray Imaging of Sublimating Spin-Frozen Solutions

Spin-freeze-drying is a promising technique to enable long-term storage of pharmaceutical unit doses of aqueous drug solutions. To investigate the sublimation of the ice during the primary phase of freeze-drying, X-ray imaging can yield crucial temporally resolved information on the local dynamics....

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Detalles Bibliográficos
Autores principales: Goethals, Wannes, Vanbillemont, Brecht, Lammens, Joris, De Beer, Thomas, Vervaet, Chris, Boone, Matthieu N.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7378758/
https://www.ncbi.nlm.nih.gov/pubmed/32630310
http://dx.doi.org/10.3390/ma13132953
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author Goethals, Wannes
Vanbillemont, Brecht
Lammens, Joris
De Beer, Thomas
Vervaet, Chris
Boone, Matthieu N.
author_facet Goethals, Wannes
Vanbillemont, Brecht
Lammens, Joris
De Beer, Thomas
Vervaet, Chris
Boone, Matthieu N.
author_sort Goethals, Wannes
collection PubMed
description Spin-freeze-drying is a promising technique to enable long-term storage of pharmaceutical unit doses of aqueous drug solutions. To investigate the sublimation of the ice during the primary phase of freeze-drying, X-ray imaging can yield crucial temporally resolved information on the local dynamics. In this paper, we describe a methodology to investigate the sublimation front during single unit-dose freeze-drying using 4D in-situ X-ray imaging. Three spin-frozen samples of different solutions were imaged using this methodology and the process characteristics were analysed and reduced to two-dimensional feature maps.
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spelling pubmed-73787582020-08-05 In-Situ X-ray Imaging of Sublimating Spin-Frozen Solutions Goethals, Wannes Vanbillemont, Brecht Lammens, Joris De Beer, Thomas Vervaet, Chris Boone, Matthieu N. Materials (Basel) Article Spin-freeze-drying is a promising technique to enable long-term storage of pharmaceutical unit doses of aqueous drug solutions. To investigate the sublimation of the ice during the primary phase of freeze-drying, X-ray imaging can yield crucial temporally resolved information on the local dynamics. In this paper, we describe a methodology to investigate the sublimation front during single unit-dose freeze-drying using 4D in-situ X-ray imaging. Three spin-frozen samples of different solutions were imaged using this methodology and the process characteristics were analysed and reduced to two-dimensional feature maps. MDPI 2020-07-01 /pmc/articles/PMC7378758/ /pubmed/32630310 http://dx.doi.org/10.3390/ma13132953 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Goethals, Wannes
Vanbillemont, Brecht
Lammens, Joris
De Beer, Thomas
Vervaet, Chris
Boone, Matthieu N.
In-Situ X-ray Imaging of Sublimating Spin-Frozen Solutions
title In-Situ X-ray Imaging of Sublimating Spin-Frozen Solutions
title_full In-Situ X-ray Imaging of Sublimating Spin-Frozen Solutions
title_fullStr In-Situ X-ray Imaging of Sublimating Spin-Frozen Solutions
title_full_unstemmed In-Situ X-ray Imaging of Sublimating Spin-Frozen Solutions
title_short In-Situ X-ray Imaging of Sublimating Spin-Frozen Solutions
title_sort in-situ x-ray imaging of sublimating spin-frozen solutions
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7378758/
https://www.ncbi.nlm.nih.gov/pubmed/32630310
http://dx.doi.org/10.3390/ma13132953
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