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Spectrum of TP53 Mutations in BRCA1/2 Associated High-Grade Serous Ovarian Cancer
Objective: Mutations in TP53 lead to loss of function (LOF) or gain of function (GOF) of the corresponding protein p53 and produce a different effect on the tumor. Our goal was to determine the spectrum of somatic TP53 variants in BRCA1/2 associated high-grade serous ovarian cancer (HGSOC). Methods:...
Autores principales: | Boyarskikh, Ulyana A., Gulyaeva, L. F., Avdalyan, A. M., Kechin, A. A., Khrapov, E. A., Lazareva, D. G., Kushlinskii, N. E., Melkonyan, A., Arakelyan, A., Filipenko, Maxim Leonidovich |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7378769/ https://www.ncbi.nlm.nih.gov/pubmed/32766142 http://dx.doi.org/10.3389/fonc.2020.01103 |
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