Investigating the pathogenic SNPs in BLM helicase and their biological consequences by computational approach

The BLM helicase protein plays a vital role in DNA replication and the maintenance of genomic integrity. Variation in the BLM helicase gene resulted in defects in the DNA repair mechanism and was reported to be associated with Bloom syndrome (BS) and cancer. Despite extensive investigation of helica...

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Detalles Bibliográficos
Autores principales: Alzahrani, Faisal A., Ahmed, Firoz, Sharma, Monika, Rehan, Mohd, Mahfuz, Maryam, Baeshen, Mohammed N., Hawsawi, Yousef, Almatrafi, Ahmed, Alsagaby, Suliman Abdallah, Kamal, Mohammad Azhar, Warsi, Mohiuddin Khan, Choudhry, Hani, Jamal, Mohammad Sarwar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7378827/
https://www.ncbi.nlm.nih.gov/pubmed/32704157
http://dx.doi.org/10.1038/s41598-020-69033-8

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