TaqMan-MGB probe quantitative PCR assays to genotype and quantify three mtDNA mutations of Leber hereditary optic neuropathy

Leber hereditary optic neuropathy (LHON) is a degenerative disease of the optic nerve associated with one of three mitochondrial DNA (mtDNA) m.3460G>A, m.11778G>A and m.14484T>C mutations. Although several procedures are available to genotype these mutations, quantitative approaches with ra...

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Detalles Bibliográficos
Autores principales: Xue, Bingqian, Li, Yang, Wang, Xin, Li, Rui, Zeng, Xin, Yang, Meihua, Xu, Xiaohui, Ye, Tingbo, Bao, Liming, Huang, Yi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7378831/
https://www.ncbi.nlm.nih.gov/pubmed/32704028
http://dx.doi.org/10.1038/s41598-020-69220-7

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