The Distinct Role of Tcfs and Lef1 in the Self-Renewal or Differentiation of Mouse Embryonic Stem Cells

BACKGROUND AND OBJECTIVES: Tcfs and Lef1 are DNA-binding transcriptional factors in the canonical Wnt signaling pathway. In the absence of β-catenin, Tcfs and Lef1 generally act as transcriptional repressors with co-repressor proteins such as Groucho, CtBP, and HIC-5. However, Tcfs and Lef1 turn int...

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Detalles Bibliográficos
Autores principales: Kim, Sewoon, Kim, Hanjun, Tan, Anderson, Song, Yonghee, Lee, Hyeju, Ying, Qi-Long, Jho, Eek-hoon
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Korean Society for Stem Cell Research 2020
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7378906/
https://www.ncbi.nlm.nih.gov/pubmed/32587136
http://dx.doi.org/10.15283/ijsc20044

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