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OEsophageal Ion Transport Mechanisms and Significance Under Pathological Conditions
Ion transporters play an important role in several physiological functions, such as cell volume regulation, pH homeostasis and secretion. In the oesophagus, ion transport proteins are part of the epithelial resistance, a mechanism which protects the oesophagus against reflux-induced damage. A change...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7379034/ https://www.ncbi.nlm.nih.gov/pubmed/32765303 http://dx.doi.org/10.3389/fphys.2020.00855 |
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author | Becskeházi, Eszter Korsós, Marietta Margaréta Erőss, Bálint Hegyi, Péter Venglovecz, Viktória |
author_facet | Becskeházi, Eszter Korsós, Marietta Margaréta Erőss, Bálint Hegyi, Péter Venglovecz, Viktória |
author_sort | Becskeházi, Eszter |
collection | PubMed |
description | Ion transporters play an important role in several physiological functions, such as cell volume regulation, pH homeostasis and secretion. In the oesophagus, ion transport proteins are part of the epithelial resistance, a mechanism which protects the oesophagus against reflux-induced damage. A change in the function or expression of ion transporters has significance in the development or neoplastic progression of Barrett’s oesophagus (BO). In this review, we discuss the physiological and pathophysiological roles of ion transporters in the oesophagus, highlighting transport proteins which serve as therapeutic targets or prognostic markers in eosinophilic oesophagitis, BO and esophageal cancer. We believe that this review highlights important relationships which might contribute to a better understanding of the pathomechanisms of esophageal diseases. |
format | Online Article Text |
id | pubmed-7379034 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-73790342020-08-05 OEsophageal Ion Transport Mechanisms and Significance Under Pathological Conditions Becskeházi, Eszter Korsós, Marietta Margaréta Erőss, Bálint Hegyi, Péter Venglovecz, Viktória Front Physiol Physiology Ion transporters play an important role in several physiological functions, such as cell volume regulation, pH homeostasis and secretion. In the oesophagus, ion transport proteins are part of the epithelial resistance, a mechanism which protects the oesophagus against reflux-induced damage. A change in the function or expression of ion transporters has significance in the development or neoplastic progression of Barrett’s oesophagus (BO). In this review, we discuss the physiological and pathophysiological roles of ion transporters in the oesophagus, highlighting transport proteins which serve as therapeutic targets or prognostic markers in eosinophilic oesophagitis, BO and esophageal cancer. We believe that this review highlights important relationships which might contribute to a better understanding of the pathomechanisms of esophageal diseases. Frontiers Media S.A. 2020-07-16 /pmc/articles/PMC7379034/ /pubmed/32765303 http://dx.doi.org/10.3389/fphys.2020.00855 Text en Copyright © 2020 Becskeházi, Korsós, Erőss, Hegyi and Venglovecz. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Physiology Becskeházi, Eszter Korsós, Marietta Margaréta Erőss, Bálint Hegyi, Péter Venglovecz, Viktória OEsophageal Ion Transport Mechanisms and Significance Under Pathological Conditions |
title | OEsophageal Ion Transport Mechanisms and Significance Under Pathological Conditions |
title_full | OEsophageal Ion Transport Mechanisms and Significance Under Pathological Conditions |
title_fullStr | OEsophageal Ion Transport Mechanisms and Significance Under Pathological Conditions |
title_full_unstemmed | OEsophageal Ion Transport Mechanisms and Significance Under Pathological Conditions |
title_short | OEsophageal Ion Transport Mechanisms and Significance Under Pathological Conditions |
title_sort | oesophageal ion transport mechanisms and significance under pathological conditions |
topic | Physiology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7379034/ https://www.ncbi.nlm.nih.gov/pubmed/32765303 http://dx.doi.org/10.3389/fphys.2020.00855 |
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