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Repositioning Quinacrine Toward Treatment of Ovarian Cancer by Rational Combination With TRAIL

Quinacrine has been identified as a potent DR5-inducing agent that sensitizes cancer cells to TRAIL-induced apoptosis. In the current study, we found that quinacrine increased DR5 mRNA levels significantly in ovarian cancer cell lines regardless of p53 status. Further study showed the half-life of D...

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Detalles Bibliográficos
Autores principales:	Liang, Rui, Yao, Yuanfei, Wang, Guangyu, Yue, Er, Yang, Guangchao, Qi, Xiuying, Wang, Yang, Zhao, Ling, Zheng, Tongsen, Zhang, Yanqiao, Wenge Wang, Edward
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2020
Materias:	Oncology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7379129/ https://www.ncbi.nlm.nih.gov/pubmed/32766144 http://dx.doi.org/10.3389/fonc.2020.01118

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