Machine learning guided association of adverse drug reactions with in vitro target-based pharmacology

BACKGROUND: Adverse drug reactions (ADRs) are one of the leading causes of morbidity and mortality in health care. Understanding which drug targets are linked to ADRs can lead to the development of safer medicines. METHODS: Here, we analyse in vitro secondary pharmacology of common (off) targets for...

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Detalles Bibliográficos
Autores principales: Ietswaart, Robert, Arat, Seda, Chen, Amanda X., Farahmand, Saman, Kim, Bumjun, DuMouchel, William, Armstrong, Duncan, Fekete, Alexander, Sutherland, Jeffrey J., Urban, Laszlo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2020
Materias:
Research paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7379147/
https://www.ncbi.nlm.nih.gov/pubmed/32565027
http://dx.doi.org/10.1016/j.ebiom.2020.102837

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