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Do neurologists agree in diagnosing drug resistance in adults with focal epilepsy?

OBJECTIVE: To evaluate interrater agreement in categorizing treatment outcomes and drug responsiveness status according to the International League Against Epilepsy (ILAE) definition of drug‐resistant epilepsy. METHODS: A total of 1053 adults with focal epilepsy considered by the investigators to me...

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Autores principales: Zaccara, Gaetano, Mula, Marco, Ferrò, Bruno, Consoli, Domenico, Elia, Maurizio, Giallonardo, Anna Teresa, Iudice, Alfonso, La Neve, Angela, Meletti, Stefano, Tinuper, Paolo, Zummo, Leila, Perucca, Emilio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7379205/
https://www.ncbi.nlm.nih.gov/pubmed/30585315
http://dx.doi.org/10.1111/epi.14622
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author Zaccara, Gaetano
Mula, Marco
Ferrò, Bruno
Consoli, Domenico
Elia, Maurizio
Giallonardo, Anna Teresa
Iudice, Alfonso
La Neve, Angela
Meletti, Stefano
Tinuper, Paolo
Zummo, Leila
Perucca, Emilio
author_facet Zaccara, Gaetano
Mula, Marco
Ferrò, Bruno
Consoli, Domenico
Elia, Maurizio
Giallonardo, Anna Teresa
Iudice, Alfonso
La Neve, Angela
Meletti, Stefano
Tinuper, Paolo
Zummo, Leila
Perucca, Emilio
author_sort Zaccara, Gaetano
collection PubMed
description OBJECTIVE: To evaluate interrater agreement in categorizing treatment outcomes and drug responsiveness status according to the International League Against Epilepsy (ILAE) definition of drug‐resistant epilepsy. METHODS: A total of 1053 adults with focal epilepsy considered by the investigators to meet ILAE criteria for drug resistance were enrolled consecutively at 43 centers and followed up prospectively for 18‐34 months. Treatment outcomes for all antiepileptic drugs (AEDs) used up to enrollment (retrospective assessment), and on an AED newly introduced at enrollment, were categorized by individual investigators and by 2 rotating members of a 16‐member expert panel (EP) that reviewed the patient records independently. Interrater agreement was tested by Cohen’s kappa (k) statistics and rated according to Landis and Koch’s criteria. RESULTS: Agreement between EP members in categorizing outcomes on the newly introduced AED was almost perfect (90.1%, k = 0.84, 95% confidence interval [CI] 0.80‐0.87), whereas agreement between the EP and individual investigators was moderate (70.4%, k = 0.57, 95% CI 0.53‐0.61). Similarly, categorization of outcomes on previously used AEDs was almost perfect between EP members (91.7%, k = 0.83, 95% CI 0.81‐0.84) and moderate between the EP and investigators (68.2%, k = 0.50, 95% CI 0.48‐0.52). Disagreement was related predominantly to outcomes considered to be treatment failures by the investigators but categorized as undetermined by the EP. Overall, 19% of patients classified as having drug‐resistant epilepsy by the investigators were considered by the EP to have “undefined responsiveness.” SIGNIFICANCE: Interrater agreement in categorizing treatment outcomes according to ILAE criteria ranges from moderate to almost perfect. Nearly 1 in 5 patients considered by enrolling neurologists to be “drug‐resistant” were classified by the EP as having “undefined responsiveness.”
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spelling pubmed-73792052020-07-24 Do neurologists agree in diagnosing drug resistance in adults with focal epilepsy? Zaccara, Gaetano Mula, Marco Ferrò, Bruno Consoli, Domenico Elia, Maurizio Giallonardo, Anna Teresa Iudice, Alfonso La Neve, Angela Meletti, Stefano Tinuper, Paolo Zummo, Leila Perucca, Emilio Epilepsia Full‐length Original Research OBJECTIVE: To evaluate interrater agreement in categorizing treatment outcomes and drug responsiveness status according to the International League Against Epilepsy (ILAE) definition of drug‐resistant epilepsy. METHODS: A total of 1053 adults with focal epilepsy considered by the investigators to meet ILAE criteria for drug resistance were enrolled consecutively at 43 centers and followed up prospectively for 18‐34 months. Treatment outcomes for all antiepileptic drugs (AEDs) used up to enrollment (retrospective assessment), and on an AED newly introduced at enrollment, were categorized by individual investigators and by 2 rotating members of a 16‐member expert panel (EP) that reviewed the patient records independently. Interrater agreement was tested by Cohen’s kappa (k) statistics and rated according to Landis and Koch’s criteria. RESULTS: Agreement between EP members in categorizing outcomes on the newly introduced AED was almost perfect (90.1%, k = 0.84, 95% confidence interval [CI] 0.80‐0.87), whereas agreement between the EP and individual investigators was moderate (70.4%, k = 0.57, 95% CI 0.53‐0.61). Similarly, categorization of outcomes on previously used AEDs was almost perfect between EP members (91.7%, k = 0.83, 95% CI 0.81‐0.84) and moderate between the EP and investigators (68.2%, k = 0.50, 95% CI 0.48‐0.52). Disagreement was related predominantly to outcomes considered to be treatment failures by the investigators but categorized as undetermined by the EP. Overall, 19% of patients classified as having drug‐resistant epilepsy by the investigators were considered by the EP to have “undefined responsiveness.” SIGNIFICANCE: Interrater agreement in categorizing treatment outcomes according to ILAE criteria ranges from moderate to almost perfect. Nearly 1 in 5 patients considered by enrolling neurologists to be “drug‐resistant” were classified by the EP as having “undefined responsiveness.” John Wiley and Sons Inc. 2018-12-25 2019-01 /pmc/articles/PMC7379205/ /pubmed/30585315 http://dx.doi.org/10.1111/epi.14622 Text en © 2018 The Authors Epilepsia published by Wiley Periodicals, Inc. on behalf of International League Against Epilepsy This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.
spellingShingle Full‐length Original Research
Zaccara, Gaetano
Mula, Marco
Ferrò, Bruno
Consoli, Domenico
Elia, Maurizio
Giallonardo, Anna Teresa
Iudice, Alfonso
La Neve, Angela
Meletti, Stefano
Tinuper, Paolo
Zummo, Leila
Perucca, Emilio
Do neurologists agree in diagnosing drug resistance in adults with focal epilepsy?
title Do neurologists agree in diagnosing drug resistance in adults with focal epilepsy?
title_full Do neurologists agree in diagnosing drug resistance in adults with focal epilepsy?
title_fullStr Do neurologists agree in diagnosing drug resistance in adults with focal epilepsy?
title_full_unstemmed Do neurologists agree in diagnosing drug resistance in adults with focal epilepsy?
title_short Do neurologists agree in diagnosing drug resistance in adults with focal epilepsy?
title_sort do neurologists agree in diagnosing drug resistance in adults with focal epilepsy?
topic Full‐length Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7379205/
https://www.ncbi.nlm.nih.gov/pubmed/30585315
http://dx.doi.org/10.1111/epi.14622
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