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Passive exposure to heat improves glucose metabolism in overweight humans

AIM: Heat exposure has been indicated to positively affect glucose metabolism. An involvement of heat shock protein 72 (HSP72) in the enhancement of insulin sensitivity upon heat exposure has been previously suggested. Here, we performed an intervention study exploring the effect of passive heat acc...

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Autores principales: Pallubinsky, Hannah, Phielix, Esther, Dautzenberg, Bas, Schaart, Gert, Connell, Niels J., de Wit‐Verheggen, Vera, Havekes, Bas, van Baak, Marleen A., Schrauwen, Patrick, van Marken Lichtenbelt, Wouter D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7379279/
https://www.ncbi.nlm.nih.gov/pubmed/32359193
http://dx.doi.org/10.1111/apha.13488
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author Pallubinsky, Hannah
Phielix, Esther
Dautzenberg, Bas
Schaart, Gert
Connell, Niels J.
de Wit‐Verheggen, Vera
Havekes, Bas
van Baak, Marleen A.
Schrauwen, Patrick
van Marken Lichtenbelt, Wouter D.
author_facet Pallubinsky, Hannah
Phielix, Esther
Dautzenberg, Bas
Schaart, Gert
Connell, Niels J.
de Wit‐Verheggen, Vera
Havekes, Bas
van Baak, Marleen A.
Schrauwen, Patrick
van Marken Lichtenbelt, Wouter D.
author_sort Pallubinsky, Hannah
collection PubMed
description AIM: Heat exposure has been indicated to positively affect glucose metabolism. An involvement of heat shock protein 72 (HSP72) in the enhancement of insulin sensitivity upon heat exposure has been previously suggested. Here, we performed an intervention study exploring the effect of passive heat acclimation (PHA) on glucose metabolism and intracellular (a) HSP72 concentrations in overweight humans. METHODS: Eleven non‐diabetic overweight (BMI 27‐35 kg/m(2)) participants underwent 10 consecutive days of PHA (4‐6 h/day, 34.4 ± 0.2°C, 22.8 ± 2.7%RH). Before and after PHA, whole‐body insulin sensitivity was assessed using a one‐step hyperinsulinaemic‐euglycaemic clamp, skeletal muscle biopsies were taken to measure intracellular iHSP72, energy expenditure and substrate oxidation were measured using indirect calorimetry and blood samples were drawn to assess markers of metabolic health. Thermophysiological adaptations were measured during a temperature ramp protocol before and after PHA. RESULTS: Despite a lack of change in iHSP72, 10 days of PHA reduced basal (9.7 ± 1.4 pre‐ vs 8.4 ± 2.1 μmol · kg(–1) · min(–1) post‐PHA, P = .038) and insulin‐stimulated (2.1 ± 0.9 pre‐ vs 1.5 ± 0.8 μmol · kg(–1) · min(–1) post‐PHA, P = .005) endogenous glucose production (EGP) and increased insulin suppression of EGP (78.5 ± 9.7% pre‐ vs 83.0 ± 7.9% post‐PHA, P = .028). Consistently, fasting plasma glucose (6.0 ± 0.5 pre‐ vs 5.8 ± 0.4 mmol/L post‐PHA, P = .013) and insulin concentrations (97 ± 55 pre‐ vs 84 ± 49 pmol/L post‐PHA, P = .026) decreased significantly. Moreover, fat oxidation increased, and free fatty acids as well as cholesterol concentrations and mean arterial pressure decreased after PHA. CONCLUSION: Our results show that PHA for 10 days improves glucose metabolism and enhances fat metabolism, without changes in iHSP72. Further exploration of the therapeutic role of heat in cardio‐metabolic disorders should be considered.
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spelling pubmed-73792792020-07-24 Passive exposure to heat improves glucose metabolism in overweight humans Pallubinsky, Hannah Phielix, Esther Dautzenberg, Bas Schaart, Gert Connell, Niels J. de Wit‐Verheggen, Vera Havekes, Bas van Baak, Marleen A. Schrauwen, Patrick van Marken Lichtenbelt, Wouter D. Acta Physiol (Oxf) Chronobiology and Endocrinology AIM: Heat exposure has been indicated to positively affect glucose metabolism. An involvement of heat shock protein 72 (HSP72) in the enhancement of insulin sensitivity upon heat exposure has been previously suggested. Here, we performed an intervention study exploring the effect of passive heat acclimation (PHA) on glucose metabolism and intracellular (a) HSP72 concentrations in overweight humans. METHODS: Eleven non‐diabetic overweight (BMI 27‐35 kg/m(2)) participants underwent 10 consecutive days of PHA (4‐6 h/day, 34.4 ± 0.2°C, 22.8 ± 2.7%RH). Before and after PHA, whole‐body insulin sensitivity was assessed using a one‐step hyperinsulinaemic‐euglycaemic clamp, skeletal muscle biopsies were taken to measure intracellular iHSP72, energy expenditure and substrate oxidation were measured using indirect calorimetry and blood samples were drawn to assess markers of metabolic health. Thermophysiological adaptations were measured during a temperature ramp protocol before and after PHA. RESULTS: Despite a lack of change in iHSP72, 10 days of PHA reduced basal (9.7 ± 1.4 pre‐ vs 8.4 ± 2.1 μmol · kg(–1) · min(–1) post‐PHA, P = .038) and insulin‐stimulated (2.1 ± 0.9 pre‐ vs 1.5 ± 0.8 μmol · kg(–1) · min(–1) post‐PHA, P = .005) endogenous glucose production (EGP) and increased insulin suppression of EGP (78.5 ± 9.7% pre‐ vs 83.0 ± 7.9% post‐PHA, P = .028). Consistently, fasting plasma glucose (6.0 ± 0.5 pre‐ vs 5.8 ± 0.4 mmol/L post‐PHA, P = .013) and insulin concentrations (97 ± 55 pre‐ vs 84 ± 49 pmol/L post‐PHA, P = .026) decreased significantly. Moreover, fat oxidation increased, and free fatty acids as well as cholesterol concentrations and mean arterial pressure decreased after PHA. CONCLUSION: Our results show that PHA for 10 days improves glucose metabolism and enhances fat metabolism, without changes in iHSP72. Further exploration of the therapeutic role of heat in cardio‐metabolic disorders should be considered. John Wiley and Sons Inc. 2020-06-01 2020-08 /pmc/articles/PMC7379279/ /pubmed/32359193 http://dx.doi.org/10.1111/apha.13488 Text en © 2020 The Authors. Acta Physiologica published by John Wiley & Sons Ltd on behalf of Scandinavian Physiological Society This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Chronobiology and Endocrinology
Pallubinsky, Hannah
Phielix, Esther
Dautzenberg, Bas
Schaart, Gert
Connell, Niels J.
de Wit‐Verheggen, Vera
Havekes, Bas
van Baak, Marleen A.
Schrauwen, Patrick
van Marken Lichtenbelt, Wouter D.
Passive exposure to heat improves glucose metabolism in overweight humans
title Passive exposure to heat improves glucose metabolism in overweight humans
title_full Passive exposure to heat improves glucose metabolism in overweight humans
title_fullStr Passive exposure to heat improves glucose metabolism in overweight humans
title_full_unstemmed Passive exposure to heat improves glucose metabolism in overweight humans
title_short Passive exposure to heat improves glucose metabolism in overweight humans
title_sort passive exposure to heat improves glucose metabolism in overweight humans
topic Chronobiology and Endocrinology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7379279/
https://www.ncbi.nlm.nih.gov/pubmed/32359193
http://dx.doi.org/10.1111/apha.13488
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