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Integrated Analysis of Prognostic and Immune Associated Integrin Family in Ovarian Cancer
Human integrin receptors are important for cell-cell and cell-matrix adhesion in normal epithelial cells. Emerging evidences have indicated integrin members are involved in cancer development and progression as well. However, the expression patterns and clinical significance of the whole integrin fa...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Frontiers Media S.A.
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7379341/ https://www.ncbi.nlm.nih.gov/pubmed/32765584 http://dx.doi.org/10.3389/fgene.2020.00705 |
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author | Wu, Anqi Zhang, Sai Liu, Jiaqi Huang, Yifeng Deng, Wenyu Shu, Guang Yin, Gang |
author_facet | Wu, Anqi Zhang, Sai Liu, Jiaqi Huang, Yifeng Deng, Wenyu Shu, Guang Yin, Gang |
author_sort | Wu, Anqi |
collection | PubMed |
description | Human integrin receptors are important for cell-cell and cell-matrix adhesion in normal epithelial cells. Emerging evidences have indicated integrin members are involved in cancer development and progression as well. However, the expression patterns and clinical significance of the whole integrin family in ovarian cancer (OC) have not yet been well understood. In the present study, we utilized the public datasets including GEPIA, GEO, ONCOMINE, cBioPortal, Kaplan-Meier Plotter, TIMER databases, to analyze the expression and prognostic value of integrin members in OC. We found ITGA3/B4/B6/B7/B8 were abnormally overexpressed in OC; ITGA6 was good prognosis predictor in OC; ITGA3/ B4/B8 were poor prognosis predictor specially in advanced OC patients; elevated ITGA3/B4 might promote metastasis and elevated ITGA3/B8 might promote platinum resistance of OC; ITGA3 and ITGB4 might synergistically or independently regulate cell adhesion and proliferation; ITGA4/AL/AM/AX/B2/B7 showed strong correlations with various tumor immune infiltrates (TILs), especially with pro-tumor immunes cell types like monocyte, M2 macrophage and exhaustion T cells infiltration; ITGAL/AM/B2/B7 and residing memory CD8+ T cells marker ITGAE were specially associated with early OC patients outcome. Our results implied that ITGA3/B4 were important prognostic markers of advanced OC, ITGAL/AM/ B2/B7 were immune associated prognosis markers of early OC, together they might render important therapeutic targets for OC. |
format | Online Article Text |
id | pubmed-7379341 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-73793412020-08-05 Integrated Analysis of Prognostic and Immune Associated Integrin Family in Ovarian Cancer Wu, Anqi Zhang, Sai Liu, Jiaqi Huang, Yifeng Deng, Wenyu Shu, Guang Yin, Gang Front Genet Genetics Human integrin receptors are important for cell-cell and cell-matrix adhesion in normal epithelial cells. Emerging evidences have indicated integrin members are involved in cancer development and progression as well. However, the expression patterns and clinical significance of the whole integrin family in ovarian cancer (OC) have not yet been well understood. In the present study, we utilized the public datasets including GEPIA, GEO, ONCOMINE, cBioPortal, Kaplan-Meier Plotter, TIMER databases, to analyze the expression and prognostic value of integrin members in OC. We found ITGA3/B4/B6/B7/B8 were abnormally overexpressed in OC; ITGA6 was good prognosis predictor in OC; ITGA3/ B4/B8 were poor prognosis predictor specially in advanced OC patients; elevated ITGA3/B4 might promote metastasis and elevated ITGA3/B8 might promote platinum resistance of OC; ITGA3 and ITGB4 might synergistically or independently regulate cell adhesion and proliferation; ITGA4/AL/AM/AX/B2/B7 showed strong correlations with various tumor immune infiltrates (TILs), especially with pro-tumor immunes cell types like monocyte, M2 macrophage and exhaustion T cells infiltration; ITGAL/AM/B2/B7 and residing memory CD8+ T cells marker ITGAE were specially associated with early OC patients outcome. Our results implied that ITGA3/B4 were important prognostic markers of advanced OC, ITGAL/AM/ B2/B7 were immune associated prognosis markers of early OC, together they might render important therapeutic targets for OC. Frontiers Media S.A. 2020-07-17 /pmc/articles/PMC7379341/ /pubmed/32765584 http://dx.doi.org/10.3389/fgene.2020.00705 Text en Copyright © 2020 Wu, Zhang, Liu, Huang, Deng, Shu and Yin. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Genetics Wu, Anqi Zhang, Sai Liu, Jiaqi Huang, Yifeng Deng, Wenyu Shu, Guang Yin, Gang Integrated Analysis of Prognostic and Immune Associated Integrin Family in Ovarian Cancer |
title | Integrated Analysis of Prognostic and Immune Associated Integrin Family in Ovarian Cancer |
title_full | Integrated Analysis of Prognostic and Immune Associated Integrin Family in Ovarian Cancer |
title_fullStr | Integrated Analysis of Prognostic and Immune Associated Integrin Family in Ovarian Cancer |
title_full_unstemmed | Integrated Analysis of Prognostic and Immune Associated Integrin Family in Ovarian Cancer |
title_short | Integrated Analysis of Prognostic and Immune Associated Integrin Family in Ovarian Cancer |
title_sort | integrated analysis of prognostic and immune associated integrin family in ovarian cancer |
topic | Genetics |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7379341/ https://www.ncbi.nlm.nih.gov/pubmed/32765584 http://dx.doi.org/10.3389/fgene.2020.00705 |
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