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M2-Like Tumor-Associated Macrophage-Targeted Codelivery of STAT6 Inhibitor and IKKβ siRNA Induces M2-to-M1 Repolarization for Cancer Immunotherapy with Low Immune Side Effects

[Image: see text] Tumor-associated macrophages (TAMs) usually display the tumor-promoting M2 phenotype rather than the tumoricidal M1 phenotype. Thus, M2-to-M1 repolarization of TAMs has emerged as a promising strategy for tumor immunotherapy nowadays. However, immune side effects remain a great cha...

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Detalles Bibliográficos
Autores principales: Xiao, Hong, Guo, Yu, Li, Bo, Li, Xiaoxia, Wang, Yong, Han, Shisong, Cheng, Du, Shuai, Xintao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2020
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7379385/
https://www.ncbi.nlm.nih.gov/pubmed/32724855
http://dx.doi.org/10.1021/acscentsci.9b01235