Cargando…
Native Mass Spectrometry Can Effectively Predict PROTAC Efficacy
[Image: see text] Protein degraders, also known as proteolysis targeting chimeras (PROTACs), are bifunctional small molecules that promote cellular degradation of a protein of interest (POI). PROTACs act as molecular mediators, bringing an E3 ligase and a POI into proximity, thus promoting ubiquitin...
| Autores principales: | , , , , , |
|---|---|
| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
American Chemical Society
2020
|
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7379389/ https://www.ncbi.nlm.nih.gov/pubmed/32724856 http://dx.doi.org/10.1021/acscentsci.0c00049 |