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Clinical characteristics and long-term outcome of Takayasu arteritis in Iran: a multicentre study
BACKGROUND/AIM: This study aimed to evaluate the demographic, clinical, angiographic and prognostic characteristics of Takayasu arteritis (TA) in Iran. MATERIALS AND METHODS: A total of 75 patients with TA based on the American College of Rheumatology 1990 criteria for TA classification referred to...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The Scientific and Technological Research Council of Turkey
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7379441/ https://www.ncbi.nlm.nih.gov/pubmed/32093440 http://dx.doi.org/10.3906/sag-1910-19 |
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author | MALEK MAHDAVI, Aida RASHTCHIZADEH, Nadereh KAVANDI, Hadise HAJIALILO, Mehrzad KOLAHI, Sousan JAFARI NAKHJAVANI, Mohammad Reza EBRAHIMI, Ali-asghar SEYEDMARDANI, Seyedmostafa SALESI, Mansour SOROUSH, Mohsen KHABBAZI, Alireza |
author_facet | MALEK MAHDAVI, Aida RASHTCHIZADEH, Nadereh KAVANDI, Hadise HAJIALILO, Mehrzad KOLAHI, Sousan JAFARI NAKHJAVANI, Mohammad Reza EBRAHIMI, Ali-asghar SEYEDMARDANI, Seyedmostafa SALESI, Mansour SOROUSH, Mohsen KHABBAZI, Alireza |
author_sort | MALEK MAHDAVI, Aida |
collection | PubMed |
description | BACKGROUND/AIM: This study aimed to evaluate the demographic, clinical, angiographic and prognostic characteristics of Takayasu arteritis (TA) in Iran. MATERIALS AND METHODS: A total of 75 patients with TA based on the American College of Rheumatology 1990 criteria for TA classification referred to the Rheumatology Centres, were followed-up from 1989 to 2019. Demographic, clinical, angiographic and prognostic characteristics were collected at baseline and last visit. RESULTS: The mean age was 31.9 ± 9.8 years at the disease onset. Female to male ratio was 14. The median latency in diagnosis was 24 months. Pulse discrepancy in the arms, blood pressure discrepancy in the arms, limb claudication, hypertension and constitutional symptoms were the most common clinical features. The most common angiographic type at the time of diagnosis was Type I (42.7%). The most frequent arterial lesion was stenosis (89.4%). Subclavian, carotid and aortic arteries were the most commonly involved arteries. New lesions developed in 28.6% of patients during the 5.25-year follow-up. Vasculitis-induced chronic damage was observed in all patients. Disease activity decreased and vascular damage remained stable throughout the follow-up period. CONCLUSIONS: The clinical features and angiographic type of TA in Iran are different from most Asian countries. Differences in angiographic and clinical features may lead to delayed diagnosis. The issue of delay in diagnosis should create awareness among health care providers that TA is not a very rare disease in Iranians and failure to pay attention to warning symptoms may delay the diagnosis. |
format | Online Article Text |
id | pubmed-7379441 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | The Scientific and Technological Research Council of Turkey |
record_format | MEDLINE/PubMed |
spelling | pubmed-73794412020-07-27 Clinical characteristics and long-term outcome of Takayasu arteritis in Iran: a multicentre study MALEK MAHDAVI, Aida RASHTCHIZADEH, Nadereh KAVANDI, Hadise HAJIALILO, Mehrzad KOLAHI, Sousan JAFARI NAKHJAVANI, Mohammad Reza EBRAHIMI, Ali-asghar SEYEDMARDANI, Seyedmostafa SALESI, Mansour SOROUSH, Mohsen KHABBAZI, Alireza Turk J Med Sci Article BACKGROUND/AIM: This study aimed to evaluate the demographic, clinical, angiographic and prognostic characteristics of Takayasu arteritis (TA) in Iran. MATERIALS AND METHODS: A total of 75 patients with TA based on the American College of Rheumatology 1990 criteria for TA classification referred to the Rheumatology Centres, were followed-up from 1989 to 2019. Demographic, clinical, angiographic and prognostic characteristics were collected at baseline and last visit. RESULTS: The mean age was 31.9 ± 9.8 years at the disease onset. Female to male ratio was 14. The median latency in diagnosis was 24 months. Pulse discrepancy in the arms, blood pressure discrepancy in the arms, limb claudication, hypertension and constitutional symptoms were the most common clinical features. The most common angiographic type at the time of diagnosis was Type I (42.7%). The most frequent arterial lesion was stenosis (89.4%). Subclavian, carotid and aortic arteries were the most commonly involved arteries. New lesions developed in 28.6% of patients during the 5.25-year follow-up. Vasculitis-induced chronic damage was observed in all patients. Disease activity decreased and vascular damage remained stable throughout the follow-up period. CONCLUSIONS: The clinical features and angiographic type of TA in Iran are different from most Asian countries. Differences in angiographic and clinical features may lead to delayed diagnosis. The issue of delay in diagnosis should create awareness among health care providers that TA is not a very rare disease in Iranians and failure to pay attention to warning symptoms may delay the diagnosis. The Scientific and Technological Research Council of Turkey 2020-06-23 /pmc/articles/PMC7379441/ /pubmed/32093440 http://dx.doi.org/10.3906/sag-1910-19 Text en Copyright © 2020 The Author(s) This article is distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use and redistribution provided that the original author and source are credited. |
spellingShingle | Article MALEK MAHDAVI, Aida RASHTCHIZADEH, Nadereh KAVANDI, Hadise HAJIALILO, Mehrzad KOLAHI, Sousan JAFARI NAKHJAVANI, Mohammad Reza EBRAHIMI, Ali-asghar SEYEDMARDANI, Seyedmostafa SALESI, Mansour SOROUSH, Mohsen KHABBAZI, Alireza Clinical characteristics and long-term outcome of Takayasu arteritis in Iran: a multicentre study |
title | Clinical characteristics and long-term outcome of Takayasu arteritis in Iran: a multicentre study |
title_full | Clinical characteristics and long-term outcome of Takayasu arteritis in Iran: a multicentre study |
title_fullStr | Clinical characteristics and long-term outcome of Takayasu arteritis in Iran: a multicentre study |
title_full_unstemmed | Clinical characteristics and long-term outcome of Takayasu arteritis in Iran: a multicentre study |
title_short | Clinical characteristics and long-term outcome of Takayasu arteritis in Iran: a multicentre study |
title_sort | clinical characteristics and long-term outcome of takayasu arteritis in iran: a multicentre study |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7379441/ https://www.ncbi.nlm.nih.gov/pubmed/32093440 http://dx.doi.org/10.3906/sag-1910-19 |
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