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The effects of blood group types on the risk of COVID-19 infection and its clinical outcome

BACKGROUND/AIM: COVID-19 (Coronavirus disease of 2019) is an infectious disease outbreak later on declared as a pandemic, caused by the SARS-CoV-2 (severe acute respiratory syndrome coronavirus-2). It spreads very rapidly and can result in severe acute respiratory failure. The clinical studies have...

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Autores principales: GÖKER, Hakan, ALADAĞ-KARAKULAK, Elifcan, DEMİROĞLU, Haluk, AYAZ, Cağlayan Merve, BÜYÜKAŞIK, Yahya, İNKAYA, Ahmet Cağkan, AKSU, Salih, SAYINALP, Nilgün, C. HAZNEDAROĞLU, İbrahim, UZUN, Ömrüm, AKOVA, Murat, ÖZCEBE, Osman, ÜNAL, Serhat
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Scientific and Technological Research Council of Turkey 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7379446/
https://www.ncbi.nlm.nih.gov/pubmed/32496734
http://dx.doi.org/10.3906/sag-2005-395
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author GÖKER, Hakan
ALADAĞ-KARAKULAK, Elifcan
DEMİROĞLU, Haluk
AYAZ, Cağlayan Merve
BÜYÜKAŞIK, Yahya
İNKAYA, Ahmet Cağkan
AKSU, Salih
SAYINALP, Nilgün
C. HAZNEDAROĞLU, İbrahim
UZUN, Ömrüm
AKOVA, Murat
ÖZCEBE, Osman
ÜNAL, Serhat
author_facet GÖKER, Hakan
ALADAĞ-KARAKULAK, Elifcan
DEMİROĞLU, Haluk
AYAZ, Cağlayan Merve
BÜYÜKAŞIK, Yahya
İNKAYA, Ahmet Cağkan
AKSU, Salih
SAYINALP, Nilgün
C. HAZNEDAROĞLU, İbrahim
UZUN, Ömrüm
AKOVA, Murat
ÖZCEBE, Osman
ÜNAL, Serhat
author_sort GÖKER, Hakan
collection PubMed
description BACKGROUND/AIM: COVID-19 (Coronavirus disease of 2019) is an infectious disease outbreak later on declared as a pandemic, caused by the SARS-CoV-2 (severe acute respiratory syndrome coronavirus-2). It spreads very rapidly and can result in severe acute respiratory failure. The clinical studies have shown that advanced age and chronic diseases increase the risk of infection. However, influence of the blood groups on COVID-19 infection and its outcome remains to be confirmed. The aim of this study is to investigate whether there exists a relationship between the blood groups of the patients and risk of SARS-CoV-2 infection and the clinical outcomes in COVID-19 patients. MATERIAL AND METHOD: 186 patients with PCR confirmed diagnosis of COVID-19 were included in this study. Age, sex, blood groups, comorbidities, need for intubation and intensive care unit follow up and mortalities of the patients were analyzed retrospectively. 1881 healthy individuals, who presented to the Hacettepe University Blood Bank served as the controls. RESULTS: The most frequently detected blood group was blood group A (57%) amongst the COVID-19 patients. This was followed by blood group O (24.8%). The blood group types did not affect the clinical outcomes. The blood group A was statistically significantly more frequent among those infected with COVID-19 compared to controls (57% vs. 38%, P < 0.001; OR: 2.1). On the other hand, the frequency of blood group O was significantly lower in the COVID-19 patients, compared to the control group (24.8% vs. 37.2%, P: 0.001; OR: 1.8). CONCLUSIONS: The results of the present study suggest that while the blood group A might have a role in increased susceptibility to the COVID-19 infection, the blood group O might be somewhat protective. However, once infected, blood group type does not seem to influence clinical outcome.
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spelling pubmed-73794462020-07-27 The effects of blood group types on the risk of COVID-19 infection and its clinical outcome GÖKER, Hakan ALADAĞ-KARAKULAK, Elifcan DEMİROĞLU, Haluk AYAZ, Cağlayan Merve BÜYÜKAŞIK, Yahya İNKAYA, Ahmet Cağkan AKSU, Salih SAYINALP, Nilgün C. HAZNEDAROĞLU, İbrahim UZUN, Ömrüm AKOVA, Murat ÖZCEBE, Osman ÜNAL, Serhat Turk J Med Sci Article BACKGROUND/AIM: COVID-19 (Coronavirus disease of 2019) is an infectious disease outbreak later on declared as a pandemic, caused by the SARS-CoV-2 (severe acute respiratory syndrome coronavirus-2). It spreads very rapidly and can result in severe acute respiratory failure. The clinical studies have shown that advanced age and chronic diseases increase the risk of infection. However, influence of the blood groups on COVID-19 infection and its outcome remains to be confirmed. The aim of this study is to investigate whether there exists a relationship between the blood groups of the patients and risk of SARS-CoV-2 infection and the clinical outcomes in COVID-19 patients. MATERIAL AND METHOD: 186 patients with PCR confirmed diagnosis of COVID-19 were included in this study. Age, sex, blood groups, comorbidities, need for intubation and intensive care unit follow up and mortalities of the patients were analyzed retrospectively. 1881 healthy individuals, who presented to the Hacettepe University Blood Bank served as the controls. RESULTS: The most frequently detected blood group was blood group A (57%) amongst the COVID-19 patients. This was followed by blood group O (24.8%). The blood group types did not affect the clinical outcomes. The blood group A was statistically significantly more frequent among those infected with COVID-19 compared to controls (57% vs. 38%, P < 0.001; OR: 2.1). On the other hand, the frequency of blood group O was significantly lower in the COVID-19 patients, compared to the control group (24.8% vs. 37.2%, P: 0.001; OR: 1.8). CONCLUSIONS: The results of the present study suggest that while the blood group A might have a role in increased susceptibility to the COVID-19 infection, the blood group O might be somewhat protective. However, once infected, blood group type does not seem to influence clinical outcome. The Scientific and Technological Research Council of Turkey 2020-06-23 /pmc/articles/PMC7379446/ /pubmed/32496734 http://dx.doi.org/10.3906/sag-2005-395 Text en Copyright © 2020 The Author(s) This article is distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use and redistribution provided that the original author and source are credited.
spellingShingle Article
GÖKER, Hakan
ALADAĞ-KARAKULAK, Elifcan
DEMİROĞLU, Haluk
AYAZ, Cağlayan Merve
BÜYÜKAŞIK, Yahya
İNKAYA, Ahmet Cağkan
AKSU, Salih
SAYINALP, Nilgün
C. HAZNEDAROĞLU, İbrahim
UZUN, Ömrüm
AKOVA, Murat
ÖZCEBE, Osman
ÜNAL, Serhat
The effects of blood group types on the risk of COVID-19 infection and its clinical outcome
title The effects of blood group types on the risk of COVID-19 infection and its clinical outcome
title_full The effects of blood group types on the risk of COVID-19 infection and its clinical outcome
title_fullStr The effects of blood group types on the risk of COVID-19 infection and its clinical outcome
title_full_unstemmed The effects of blood group types on the risk of COVID-19 infection and its clinical outcome
title_short The effects of blood group types on the risk of COVID-19 infection and its clinical outcome
title_sort effects of blood group types on the risk of covid-19 infection and its clinical outcome
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7379446/
https://www.ncbi.nlm.nih.gov/pubmed/32496734
http://dx.doi.org/10.3906/sag-2005-395
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