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Analysing the blood-stemming effect of Ankaferd Blood Stopper in medulla spinalis surgery

BACKGROUND/AIM: The aim of this study was to investigate the possible toxicity of the Ankaferd Blood Stopper (ABS) on the neural system. MATERIALS AND METHODS: Thirty Sprague Dawley rats were randomized into ABS (n: 15) and control (n: 15) groups. Following the anaesthetic induction, total laminecto...

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Autores principales: TÜRKÖZ, Dursun, DEMİREL, Cem, SATALOĞLU, Hüseyin, ÇOKLUK, Cengiz
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Scientific and Technological Research Council of Turkey 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7379454/
https://www.ncbi.nlm.nih.gov/pubmed/32283888
http://dx.doi.org/10.3906/sag-2001-249
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author TÜRKÖZ, Dursun
DEMİREL, Cem
SATALOĞLU, Hüseyin
ÇOKLUK, Cengiz
author_facet TÜRKÖZ, Dursun
DEMİREL, Cem
SATALOĞLU, Hüseyin
ÇOKLUK, Cengiz
author_sort TÜRKÖZ, Dursun
collection PubMed
description BACKGROUND/AIM: The aim of this study was to investigate the possible toxicity of the Ankaferd Blood Stopper (ABS) on the neural system. MATERIALS AND METHODS: Thirty Sprague Dawley rats were randomized into ABS (n: 15) and control (n: 15) groups. Following the anaesthetic induction, total laminectomy was performed to the lower thoracic, and upper lumbar areas in both groups and medulla spinalis was exposed. Two myelotomies were performed on the medulla spinalis. One millilitre ABS was applied to the incision site in the ABS group, and one millilitre 0.9% saline solution was applied in the control group. Rats were observed for 15 days regarding general behaviour, neurological signs, mobility, and signs of infection. Sixteen days later, all rats were decapitated under anaesthesia. Medulla spinalis was removed en bloc from all rats and was stained with Heamatoxylin & Eosin and luxol fast blue. RESULTS: There was no significant difference between the ABS group and the control group regarding oedema, gliosis, the intensity of inflammatory cells, the presence of neuronal degeneration, neuron counts, and myelin degeneration. CONCLUSION: No clinical or histopathological evidence for the neurotoxic effect of the ABS was observed in the present study. Our findings might precipitate the use of ABS on human subjects regarding medulla spinalis surgery.
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spelling pubmed-73794542020-07-27 Analysing the blood-stemming effect of Ankaferd Blood Stopper in medulla spinalis surgery TÜRKÖZ, Dursun DEMİREL, Cem SATALOĞLU, Hüseyin ÇOKLUK, Cengiz Turk J Med Sci Article BACKGROUND/AIM: The aim of this study was to investigate the possible toxicity of the Ankaferd Blood Stopper (ABS) on the neural system. MATERIALS AND METHODS: Thirty Sprague Dawley rats were randomized into ABS (n: 15) and control (n: 15) groups. Following the anaesthetic induction, total laminectomy was performed to the lower thoracic, and upper lumbar areas in both groups and medulla spinalis was exposed. Two myelotomies were performed on the medulla spinalis. One millilitre ABS was applied to the incision site in the ABS group, and one millilitre 0.9% saline solution was applied in the control group. Rats were observed for 15 days regarding general behaviour, neurological signs, mobility, and signs of infection. Sixteen days later, all rats were decapitated under anaesthesia. Medulla spinalis was removed en bloc from all rats and was stained with Heamatoxylin & Eosin and luxol fast blue. RESULTS: There was no significant difference between the ABS group and the control group regarding oedema, gliosis, the intensity of inflammatory cells, the presence of neuronal degeneration, neuron counts, and myelin degeneration. CONCLUSION: No clinical or histopathological evidence for the neurotoxic effect of the ABS was observed in the present study. Our findings might precipitate the use of ABS on human subjects regarding medulla spinalis surgery. The Scientific and Technological Research Council of Turkey 2020-06-23 /pmc/articles/PMC7379454/ /pubmed/32283888 http://dx.doi.org/10.3906/sag-2001-249 Text en Copyright © 2020 The Author(s) This article is distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use and redistribution provided that the original author and source are credited.
spellingShingle Article
TÜRKÖZ, Dursun
DEMİREL, Cem
SATALOĞLU, Hüseyin
ÇOKLUK, Cengiz
Analysing the blood-stemming effect of Ankaferd Blood Stopper in medulla spinalis surgery
title Analysing the blood-stemming effect of Ankaferd Blood Stopper in medulla spinalis surgery
title_full Analysing the blood-stemming effect of Ankaferd Blood Stopper in medulla spinalis surgery
title_fullStr Analysing the blood-stemming effect of Ankaferd Blood Stopper in medulla spinalis surgery
title_full_unstemmed Analysing the blood-stemming effect of Ankaferd Blood Stopper in medulla spinalis surgery
title_short Analysing the blood-stemming effect of Ankaferd Blood Stopper in medulla spinalis surgery
title_sort analysing the blood-stemming effect of ankaferd blood stopper in medulla spinalis surgery
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7379454/
https://www.ncbi.nlm.nih.gov/pubmed/32283888
http://dx.doi.org/10.3906/sag-2001-249
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