Concise Review: Laying the Groundwork for a First‐In‐Human Study of an Induced Pluripotent Stem Cell‐Based Intervention for Spinal Cord Injury

There have been numerous attempts to develop stem cell transplantation approaches to promote the regeneration of spinal cord injury (SCI). Our multicenter team is currently planning to launch a first‐in‐human clinical study of an induced pluripotent stem cell (iPSC)‐based cell transplant interventio...

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Autores principales: Tsuji, Osahiko, Sugai, Keiko, Yamaguchi, Ryo, Tashiro, Syoichi, Nagoshi, Narihito, Kohyama, Jun, Iida, Tsuyoshi, Ohkubo, Toshiki, Itakura, Go, Isoda, Miho, Shinozaki, Munehisa, Fujiyoshi, Kanehiro, Kanemura, Yonehiro, Yamanaka, Shinya, Nakamura, Masaya, Okano, Hideyuki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley & Sons, Inc. 2018
Materias:
Embryonic Stem Cells/Induced Stem Cells
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7379555/
https://www.ncbi.nlm.nih.gov/pubmed/30371964
http://dx.doi.org/10.1002/stem.2926
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author Tsuji, Osahiko
Sugai, Keiko
Yamaguchi, Ryo
Tashiro, Syoichi
Nagoshi, Narihito
Kohyama, Jun
Iida, Tsuyoshi
Ohkubo, Toshiki
Itakura, Go
Isoda, Miho
Shinozaki, Munehisa
Fujiyoshi, Kanehiro
Kanemura, Yonehiro
Yamanaka, Shinya
Nakamura, Masaya
Okano, Hideyuki
author_facet Tsuji, Osahiko
Sugai, Keiko
Yamaguchi, Ryo
Tashiro, Syoichi
Nagoshi, Narihito
Kohyama, Jun
Iida, Tsuyoshi
Ohkubo, Toshiki
Itakura, Go
Isoda, Miho
Shinozaki, Munehisa
Fujiyoshi, Kanehiro
Kanemura, Yonehiro
Yamanaka, Shinya
Nakamura, Masaya
Okano, Hideyuki
author_sort Tsuji, Osahiko
collection PubMed
description There have been numerous attempts to develop stem cell transplantation approaches to promote the regeneration of spinal cord injury (SCI). Our multicenter team is currently planning to launch a first‐in‐human clinical study of an induced pluripotent stem cell (iPSC)‐based cell transplant intervention for subacute SCI. This trial was conducted as class I regenerative medicine protocol as provided for under Japan's Act on the Safety of Regenerative Medicine, using neural stem/progenitor cells derived from a clinical‐grade, integration‐free human “iPSC stock” generated by the Kyoto University Center for iPS Cell Research and Application. In the present article, we describe how we are preparing to initiate this clinical study, including addressing the issues of safety and tumorigenesis as well as practical problems that must be overcome to enable the development of therapeutic interventions for patients with chronic SCI. stem cells 2019;37:6–13
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spelling pubmed-73795552020-07-24 Concise Review: Laying the Groundwork for a First‐In‐Human Study of an Induced Pluripotent Stem Cell‐Based Intervention for Spinal Cord Injury Tsuji, Osahiko Sugai, Keiko Yamaguchi, Ryo Tashiro, Syoichi Nagoshi, Narihito Kohyama, Jun Iida, Tsuyoshi Ohkubo, Toshiki Itakura, Go Isoda, Miho Shinozaki, Munehisa Fujiyoshi, Kanehiro Kanemura, Yonehiro Yamanaka, Shinya Nakamura, Masaya Okano, Hideyuki Stem Cells Embryonic Stem Cells/Induced Stem Cells There have been numerous attempts to develop stem cell transplantation approaches to promote the regeneration of spinal cord injury (SCI). Our multicenter team is currently planning to launch a first‐in‐human clinical study of an induced pluripotent stem cell (iPSC)‐based cell transplant intervention for subacute SCI. This trial was conducted as class I regenerative medicine protocol as provided for under Japan's Act on the Safety of Regenerative Medicine, using neural stem/progenitor cells derived from a clinical‐grade, integration‐free human “iPSC stock” generated by the Kyoto University Center for iPS Cell Research and Application. In the present article, we describe how we are preparing to initiate this clinical study, including addressing the issues of safety and tumorigenesis as well as practical problems that must be overcome to enable the development of therapeutic interventions for patients with chronic SCI. stem cells 2019;37:6–13 John Wiley & Sons, Inc. 2018-11-12 2019-01 /pmc/articles/PMC7379555/ /pubmed/30371964 http://dx.doi.org/10.1002/stem.2926 Text en © 2018 The Authors stem cells published by Wiley Periodicals, Inc. on behalf of AlphaMed Press This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.
spellingShingle Embryonic Stem Cells/Induced Stem Cells
Tsuji, Osahiko
Sugai, Keiko
Yamaguchi, Ryo
Tashiro, Syoichi
Nagoshi, Narihito
Kohyama, Jun
Iida, Tsuyoshi
Ohkubo, Toshiki
Itakura, Go
Isoda, Miho
Shinozaki, Munehisa
Fujiyoshi, Kanehiro
Kanemura, Yonehiro
Yamanaka, Shinya
Nakamura, Masaya
Okano, Hideyuki
Concise Review: Laying the Groundwork for a First‐In‐Human Study of an Induced Pluripotent Stem Cell‐Based Intervention for Spinal Cord Injury
title Concise Review: Laying the Groundwork for a First‐In‐Human Study of an Induced Pluripotent Stem Cell‐Based Intervention for Spinal Cord Injury
title_full Concise Review: Laying the Groundwork for a First‐In‐Human Study of an Induced Pluripotent Stem Cell‐Based Intervention for Spinal Cord Injury
title_fullStr Concise Review: Laying the Groundwork for a First‐In‐Human Study of an Induced Pluripotent Stem Cell‐Based Intervention for Spinal Cord Injury
title_full_unstemmed Concise Review: Laying the Groundwork for a First‐In‐Human Study of an Induced Pluripotent Stem Cell‐Based Intervention for Spinal Cord Injury
title_short Concise Review: Laying the Groundwork for a First‐In‐Human Study of an Induced Pluripotent Stem Cell‐Based Intervention for Spinal Cord Injury
title_sort concise review: laying the groundwork for a first‐in‐human study of an induced pluripotent stem cell‐based intervention for spinal cord injury
topic Embryonic Stem Cells/Induced Stem Cells
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7379555/
https://www.ncbi.nlm.nih.gov/pubmed/30371964
http://dx.doi.org/10.1002/stem.2926
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