Cargando…

Phase 3 study of recombinant von Willebrand factor in patients with severe von Willebrand disease who are undergoing elective surgery

ESSENTIALS: Recombinant von Willebrand factor (rVWF) is effective in von Willebrand disease (VWD). A phase 3 study of rVWF, with/without recombinant factor VIII (rFVIII) before surgery in VWD. Overall rVWF's efficacy was rated excellent/good; rVWF was administered alone in most patients. rVWF w...

Descripción completa

Detalles Bibliográficos
Autores principales:	Peyvandi, F., Mamaev, A., Wang, J.‐D., Stasyshyn, O., Timofeeva, M., Curry, N., Cid, A. R., Yee, T. T., Kavakli, K., Castaman, G., Sytkowski, A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2018
Materias:	CLINICAL HAEMOSTASIS AND THROMBOSIS
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7379610/ https://www.ncbi.nlm.nih.gov/pubmed/30362288 http://dx.doi.org/10.1111/jth.14313

Ejemplares similares

Comorbidities associated with higher von Willebrand factor (VWF) levels may explain the age‐related increase of VWF in von Willebrand disease
por: Atiq, Ferdows, et al.
Publicado: (2018)

Von Willebrand factor propeptide and pathophysiological mechanisms in European and Iranian patients with type 3 von Willebrand disease enrolled in the 3WINTERS‐IPS study
por: Pagliari, Maria Teresa, et al.
Publicado: (2022)

Platelet degranulation and bleeding phenotype in a large cohort of Von Willebrand disease patients
por: Swinkels, Maurice, et al.
Publicado: (2022)

Management of von Willebrand disease with a factor VIII‐poor von Willebrand factor concentrate: Results from a prospective observational post‐marketing study
por: Goudemand, Jenny, et al.
Publicado: (2020)

Von Willebrand disease type 2M: Correlation between genotype and phenotype
por: Maas, Dominique P. M. S. M., et al.
Publicado: (2021)

Differences in von Willebrand factor function in type 2A von Willebrand disease and left ventricular assist device‐induced acquired von Willebrand syndrome
por: Deconinck, Shannen, et al.
Publicado: (2018)

Criteria for low von Willebrand factor diagnosis and risk score to predict future bleeding
por: Atiq, Ferdows, et al.
Publicado: (2021)

Evaluation of a semi‐automated von Willebrand factor multimer assay, the Hydragel 5 von Willebrand multimer, by two European Centers
por: Bowyer, Annette E., et al.
Publicado: (2018)

Phenotypic and genetic characterizations of the Milan cohort of von Willebrand disease type 2
por: Seidizadeh, Omid, et al.
Publicado: (2022)

Recombinant von Willebrand factor prophylaxis in patients with severe von Willebrand disease: phase 3 study results
por: Leebeek, Frank W. G., et al.
Publicado: (2022)

The p.P1127S pathogenic variant lowers von Willebrand factor levels through higher affinity for the macrophagic scavenger receptor LRP1: Clinical phenotype and pathogenic mechanisms
por: Sacco, Monica, et al.
Publicado: (2022)

Potent and rapid reversal of the von Willebrand factor inhibitor aptamer BT200
por: Zhu, Shuhao, et al.
Publicado: (2020)

Changes of von Willebrand Factor during Pregnancy in Women with and without von Willebrand Disease
por: Castaman, Giancarlo
Publicado: (2013)

Influence of blood group, von Willebrand factor levels, and age on factor VIII levels in non‐severe haemophilia A
por: Rejtő, Judit, et al.
Publicado: (2020)

One piece of the puzzle: Population pharmacokinetics of FVIII during perioperative Haemate P(®)/Humate P(®) treatment in von Willebrand disease patients
por: de Jager, Nico C. B., et al.
Publicado: (2019)

Von Willebrand disease type Vicenza: In search of a classification for the archetype of reduced von Willebrand factor survival
por: Casonato, Alessandra, et al.
Publicado: (2021)

The development and characterization of a long acting anti‐thrombotic von Willebrand factor (VWF) aptamer
por: Zhu, Shuhao, et al.
Publicado: (2020)

Mechano-covalent protection of coagulation factor VIII by von Willebrand factor
por: Butera, Diego, et al.
Publicado: (2022)

Combined effects of two mutations in von Willebrand disease 2M phenotype
por: Woods, Adriana I., et al.
Publicado: (2017)

Von Willebrand factor multimer quantitation for assessment of cardiac lesion severity and bleeding risk
por: Austin, Christopher O., et al.
Publicado: (2017)

Human von Willebrand factor/factor VIII concentrates in the management of pediatric patients with von Willebrand disease/hemophilia A
por: Castaman, Giancarlo, et al.
Publicado: (2016)

Identification of cysteine thiol‐based linkages in ADAMTS13 in support of a non‐proteolytic regulation of von Willebrand factor
por: Rottensteiner, Hanspeter, et al.
Publicado: (2019)

The Prevalence of von Willebrand Disease and Significance of in Vitro Bleeding Time (PFA-100) in von Willebrand Disease Screening in the İzmir Region
por: Şap, Fatih, et al.
Publicado: (2013)

von Willebrand factor antigen levels are associated with burden of rare nonsynonymous variants in the VWF gene
por: Sadler, Brooke, et al.
Publicado: (2021)

A conformational transition of the D′D3 domain primes von Willebrand factor for multimerization
por: Gruber, Sophia, et al.
Publicado: (2022)

Small interfering RNA–mediated allele-selective silencing of von Willebrand factor in vitro and in vivo
por: Jongejan, Yvonne K., et al.
Publicado: (2023)

Breast cancer cells mediate endothelial cell activation, promoting von Willebrand factor release, tumor adhesion, and transendothelial migration
por: Dhami, Sukhraj Pal Singh, et al.
Publicado: (2022)

Evaluation of von Willebrand factor concentrates by platelet adhesion to collagen using an in vitro flow assay
por: Riddell, Anne, et al.
Publicado: (2018)

Assembly of von Willebrand factor tubules with in vivo helical parameters requires A1 domain insertion
por: Javitt, Gabriel, et al.
Publicado: (2022)

A novel von Willebrand factor multimer ratio as marker of disease activity in thrombotic thrombocytopenic purpura
por: Falter, Tanja, et al.
Publicado: (2023)

Hemophilia and von Willebrand disease: Factor VIII and von Willebrand factor
por: Sharma, Prashant
Publicado: (2019)

Increased von Willebrand factor levels in polycythemia vera and phenotypic differences with essential thrombocythemia
por: Sacco, Monica, et al.
Publicado: (2020)

Diagnosis and Treatment of von Willebrand Disease and Rare Bleeding Disorders
por: Castaman, Giancarlo, et al.
Publicado: (2017)

Proximity proteomics identifies septins and PAK2 as decisive regulators of actomyosin-mediated expulsion of von Willebrand factor
por: El-Mansi, Sammy, et al.
Publicado: (2023)

The Functions of the A1A2A3 Domains in Von Willebrand Factor Include Multimerin 1 Binding
por: Parker, D’Andra N., et al.
Publicado: (2016)

Diagnostic Value of Measuring Platelet Von Willebrand Factor in Von Willebrand Disease
por: Casonato, Alessandra, et al.
Publicado: (2016)

Determination of von Willebrand factor level in patient with sickle cell diseasein vaso‐occlusive crisis
por: Akaba, Kingsley, et al.
Publicado: (2020)

Desmopressin response depends on the presence and type of genetic variants in patients with type 1 and type 2 von Willebrand disease
por: Atiq, Ferdows, et al.
Publicado: (2022)

Genetic Variation in the von Willebrand Factor Gene in Swedish von Willebrand Disease Patients
por: Manderstedt, Eric, et al.
Publicado: (2018)

Porcine and Canine von Willebrand Factor and von Willebrand Disease: Hemostasis, Thrombosis, and Atherosclerosis Studies
por: Nichols, Timothy C., et al.
Publicado: (2010)

Cannot write session to /tmp/vufind_sessions/sess_9egrj24ich7of5755pljsbdacd