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Sub-lethal doses of albendazole induce drug metabolizing enzymes and increase albendazole deactivation in Haemonchus contortus adults

The efficacy of anthelmintic therapy of farm animals rapidly decreases due to drug resistance development in helminths. In resistant isolates, the increased expression and activity of drug-metabolizing enzymes (DMEs), e.g. cytochromes P450 (CYPs), UDP-glycosyltransferases (UGTs) and P-glycoprotein t...

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Detalles Bibliográficos
Autores principales:	Kellerová, Pavlína, Raisová Stuchlíková, Lucie, Matoušková, Petra, Štěrbová, Karolína, Lamka, Jiří, Navrátilová, Martina, Vokřál, Ivan, Szotáková, Barbora, Skálová, Lenka
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2020
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7379777/ https://www.ncbi.nlm.nih.gov/pubmed/32703268 http://dx.doi.org/10.1186/s13567-020-00820-x

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