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Trem2 deficiency differentially affects phenotype and transcriptome of human APOE3 and APOE4 mice

BACKGROUND: Alzheimer’s Disease (AD) is a neurodegenerative disorder influenced by aging and genetic risk factors. The inheritance of APOEε4 and variants of Triggering Receptor Expressed on Myeloid cells 2 (TREM2) are major genetic risk factors for AD. Recent studies showed that APOE binds to TREM2,...

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Detalles Bibliográficos
Autores principales:	Fitz, Nicholas F., Wolfe, Cody M., Playso, Brittany E., Biedrzycki, Richard J., Lu, Yi, Nam, Kyong Nyon, Lefterov, Iliya, Koldamova, Radosveta
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2020
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7379780/ https://www.ncbi.nlm.nih.gov/pubmed/32703241 http://dx.doi.org/10.1186/s13024-020-00394-4

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