The glycosyltransferase EXTL2 promotes proteoglycan deposition and injurious neuroinflammation following demyelination

BACKGROUND: Chondroitin sulfate proteoglycans (CSPGs) are potent inhibitors of axonal regrowth and remyelination. More recently, they have also been highlighted as a modulator of macrophage infiltration into the central nervous system in experimental autoimmune encephalomyelitis, an inflammatory mod...

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Detalles Bibliográficos
Autores principales: Pu, Annie, Mishra, Manoj K., Dong, Yifei, Ghorbanigazar, Samira, Stephenson, Erin L., Rawji, Khalil S., Silva, Claudia, Kitagawa, Hiroshi, Sawcer, Stephen, Yong, V. Wee
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7379813/
https://www.ncbi.nlm.nih.gov/pubmed/32703234
http://dx.doi.org/10.1186/s12974-020-01895-1

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