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Effect of diabetes mellitus on survival in patients with gallbladder Cancer: a systematic review and meta-analysis

BACKGROUND: Increasing evidences indicated that diabetes might increase the incidence of gallbladder cancer. However, no sufficient data has ever clarified the impact of diabetes on the survival of patients with gallbladder cancer. METHODS: We comprehensively searched PubMed, Embase, and the Cochran...

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Autores principales: Jing, Chen, Wang, Zhengyi, Fu, Xue
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7379826/
https://www.ncbi.nlm.nih.gov/pubmed/32709224
http://dx.doi.org/10.1186/s12885-020-07139-y
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author Jing, Chen
Wang, Zhengyi
Fu, Xue
author_facet Jing, Chen
Wang, Zhengyi
Fu, Xue
author_sort Jing, Chen
collection PubMed
description BACKGROUND: Increasing evidences indicated that diabetes might increase the incidence of gallbladder cancer. However, no sufficient data has ever clarified the impact of diabetes on the survival of patients with gallbladder cancer. METHODS: We comprehensively searched PubMed, Embase, and the Cochrane Library databases through July 2019 in order to find sufficient eligible researches. The pooled hazard risks (HRs) and relative risks (RRs) with 95% confidence intervals (CIs) were calculated with either fix-effects or random-effects model. Due to the low gallbladder cancer mortality in general population, the RRs and standard mortality ratios (SMRs) were considered the similar estimates of the HRs. RESULTS: Ten eligible studies were included in this meta-analysis. Analysis of eight cohorts found that diabetes was closely associated with the mortality of gallbladder cancer (HR = 1.10; 95% CI: 1.06–1.14; P < 0.00001). However, the mortality in male diabetes patients was not higher than female patients (RR = 1.08, 95%CI = 0.57–2.04, P = 0.80). CONCLUSIONS: These findings indicated that diabetes patients had a higher mortality of gallbladder cancer compared with non-diabetes.
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spelling pubmed-73798262020-08-04 Effect of diabetes mellitus on survival in patients with gallbladder Cancer: a systematic review and meta-analysis Jing, Chen Wang, Zhengyi Fu, Xue BMC Cancer Research Article BACKGROUND: Increasing evidences indicated that diabetes might increase the incidence of gallbladder cancer. However, no sufficient data has ever clarified the impact of diabetes on the survival of patients with gallbladder cancer. METHODS: We comprehensively searched PubMed, Embase, and the Cochrane Library databases through July 2019 in order to find sufficient eligible researches. The pooled hazard risks (HRs) and relative risks (RRs) with 95% confidence intervals (CIs) were calculated with either fix-effects or random-effects model. Due to the low gallbladder cancer mortality in general population, the RRs and standard mortality ratios (SMRs) were considered the similar estimates of the HRs. RESULTS: Ten eligible studies were included in this meta-analysis. Analysis of eight cohorts found that diabetes was closely associated with the mortality of gallbladder cancer (HR = 1.10; 95% CI: 1.06–1.14; P < 0.00001). However, the mortality in male diabetes patients was not higher than female patients (RR = 1.08, 95%CI = 0.57–2.04, P = 0.80). CONCLUSIONS: These findings indicated that diabetes patients had a higher mortality of gallbladder cancer compared with non-diabetes. BioMed Central 2020-07-24 /pmc/articles/PMC7379826/ /pubmed/32709224 http://dx.doi.org/10.1186/s12885-020-07139-y Text en © The Author(s) 2020 Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Research Article
Jing, Chen
Wang, Zhengyi
Fu, Xue
Effect of diabetes mellitus on survival in patients with gallbladder Cancer: a systematic review and meta-analysis
title Effect of diabetes mellitus on survival in patients with gallbladder Cancer: a systematic review and meta-analysis
title_full Effect of diabetes mellitus on survival in patients with gallbladder Cancer: a systematic review and meta-analysis
title_fullStr Effect of diabetes mellitus on survival in patients with gallbladder Cancer: a systematic review and meta-analysis
title_full_unstemmed Effect of diabetes mellitus on survival in patients with gallbladder Cancer: a systematic review and meta-analysis
title_short Effect of diabetes mellitus on survival in patients with gallbladder Cancer: a systematic review and meta-analysis
title_sort effect of diabetes mellitus on survival in patients with gallbladder cancer: a systematic review and meta-analysis
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7379826/
https://www.ncbi.nlm.nih.gov/pubmed/32709224
http://dx.doi.org/10.1186/s12885-020-07139-y
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