RIG-1-Like Receptor Activation Synergizes With Intratumoral Alpha Radiation to Induce Pancreatic Tumor Rejection, Triple-Negative Breast Metastases Clearance, and Antitumor Immune Memory in Mice

Diffusing alpha-emitting radiation therapy (DaRT) employs intratumoral Ra-224-coated seeds that efficiently destroy solid tumors by slowly releasing alpha-emitting atoms inside the tumor. In immunogenic tumor models, DaRT was shown to activate systemic antitumor immunity. Agonists of the membrane-bo...

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Detalles Bibliográficos
Autores principales: Domankevich, Vered, Efrati, Margalit, Schmidt, Michael, Glikson, Eran, Mansour, Fairuz, Shai, Amit, Cohen, Adi, Zilberstein, Yael, Flaisher, Elad, Galalae, Razvan, Kelson, Itzhak, Keisari, Yona
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Oncology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7379859/
https://www.ncbi.nlm.nih.gov/pubmed/32766128
http://dx.doi.org/10.3389/fonc.2020.00990

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