Multiple Genomic Events Altering Hominin SIGLEC Biology and Innate Immunity Predated the Common Ancestor of Humans and Archaic Hominins

Human-specific pseudogenization of the CMAH gene eliminated the mammalian sialic acid (Sia) Neu5Gc (generating an excess of its precursor Neu5Ac), thus changing ubiquitous cell surface “self-associated molecular patterns” that modulate innate immunity via engagement of CD33-related-Siglec receptors....

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Detalles Bibliográficos
Autores principales: Khan, Naazneen, de Manuel, Marc, Peyregne, Stephane, Do, Raymond, Prufer, Kay, Marques-Bonet, Tomas, Varki, Nissi, Gagneux, Pascal, Varki, Ajit
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7379906/
https://www.ncbi.nlm.nih.gov/pubmed/32556248
http://dx.doi.org/10.1093/gbe/evaa125

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