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Propeptide glycosylation and galectin‐3 binding decrease proteolytic activation of human proMMP‐9/progelatinase B
Matrix metalloproteinases (MMPs) are secreted as proenzymes, containing propeptides that interact with the catalytic zinc, thereby controlling MMP activation. The MMP‐9 propeptide is unique in the MMP family because of its post‐translational modification with an N‐linked oligosaccharide. ProMMP‐9 ac...
Autores principales: | Boon, Lise, Ugarte‐Berzal, Estefania, Martens, Erik, Vandooren, Jennifer, Rybakin, Vasily, Colau, Didier, Gordon‐Alonso, Monica, van der Bruggen, Pierre, Stöcker, Walter, Becker‐Pauly, Christoph, Witters, Peter, Morava, Eva, Jaeken, Jaak, Proost, Paul, Opdenakker, Ghislain |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7379967/ https://www.ncbi.nlm.nih.gov/pubmed/30422384 http://dx.doi.org/10.1111/febs.14698 |
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