Cargando…

Oxiracetam Offers Neuroprotection by Reducing Amyloid β-Induced Microglial Activation and Inflammation in Alzheimer's Disease

Background: Alzheimer's disease (AD) is characterized by amyloid beta (Aβ) accumulation in the brain, which triggers the activation of microglia; in turn, microglia release neuroinflammatory factors capable of damaging neurons. Thus, a therapeutic approach targeting this sustained microglia-ind...

Descripción completa

Detalles Bibliográficos
Autores principales:	Zhang, Heng, Jia, Longfei, Jia, Jianping
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2020
Materias:	Neurology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7380077/ https://www.ncbi.nlm.nih.gov/pubmed/32765394 http://dx.doi.org/10.3389/fneur.2020.00623

Ejemplares similares

(S)-Oxiracetam is the Active Ingredient in Oxiracetam that Alleviates the Cognitive Impairment Induced by Chronic Cerebral Hypoperfusion in Rats
por: li, Wan, et al.
Publicado: (2017)

Roles of Microglial and Monocyte Chemokines and Their Receptors in Regulating Alzheimer's Disease-Associated Amyloid-β and Tau Pathologies
por: Guedes, Joana R., et al.
Publicado: (2018)

Oxiracetam or fastigial nucleus stimulation reduces cognitive injury at high altitude
por: Hu, ShengLi, et al.
Publicado: (2017)

Microglial phagocytosis induced by fibrillar β-amyloid is attenuated by oligomeric β-amyloid: implications for Alzheimer's disease
por: Pan, Xiao-dong, et al.
Publicado: (2011)

Amyloid β Induces Lipid Droplet-Mediated Microglial Dysfunction in Alzheimer’s Disease
por: Prakash, Priya, et al.
Publicado: (2023)

Nerve growth factor in combination with Oxiracetam in the treatment of Hypertensive Cerebral Hemorrhage
por: Sun, Yuzhen, et al.
Publicado: (2018)

Cromolyn Reduces Levels of the Alzheimer’s Disease-Associated Amyloid β-Protein by Promoting Microglial Phagocytosis
por: Zhang, Can, et al.
Publicado: (2018)

Integration of amyloid-β oligomerization tendency as a plasma biomarker in Alzheimer's disease diagnosis
por: Pyun, Jung-Min, et al.
Publicado: (2023)

An “Amyloid‐β Cleaner” for the Treatment of Alzheimer's Disease by Normalizing Microglial Dysfunction
por: Liu, Ruiyuan, et al.
Publicado: (2019)

Role of microglial amylin receptors in mediating beta amyloid (Aβ)-induced inflammation
por: Fu, Wen, et al.
Publicado: (2017)

Sodium rutin ameliorates Alzheimer’s disease–like pathology by enhancing microglial amyloid-β clearance
por: Pan, Rui-Yuan, et al.
Publicado: (2019)

Cu(II) enhances the effect of Alzheimer’s amyloid-β peptide on microglial activation
por: Yu, Fengxiang, et al.
Publicado: (2015)

Mesenchymal Stem Cells Provide Neuroprotection by Regulating Heat Stroke-Induced Brain Inflammation
por: Zhang, Yu, et al.
Publicado: (2020)

Isoliquiritigenin Confers Neuroprotection and Alleviates Amyloid-β42-Induced Neuroinflammation in Microglia by Regulating the Nrf2/NF-κB Signaling
por: Fu, Yue, et al.
Publicado: (2021)

Betaine Mitigates Amyloid-β-Associated Neuroinflammation by Suppressing the NLRP3 and NF-κB Signaling Pathways in Microglial Cells
por: Zhang, Yue, et al.
Publicado: (2023)

The Neuroprotective Action of Amidated-Kyotorphin on Amyloid β Peptide-Induced Alzheimer’s Disease Pathophysiology
por: Belo, Rita F., et al.
Publicado: (2020)

Novel PSEN1 (P284S) Mutation Causes Alzheimer's Disease with Cerebellar Amyloid β-Protein Deposition
por: Xia, Mingrong, et al.
Publicado: (2022)

Amyloid-Related Imaging Abnormalities With Anti-amyloid Antibodies for the Treatment of Dementia Due to Alzheimer's Disease
por: Withington, Charles G., et al.
Publicado: (2022)

Antibody-Based In Vivo PET Imaging Detects Amyloid-β Reduction in Alzheimer Transgenic Mice After BACE-1 Inhibition
por: Meier, Silvio R., et al.
Publicado: (2018)

Amyloid and tau PET in cerebral amyloid angiopathy-related inflammation two case reports and literature review
por: Yang, Jhih-Yong, et al.
Publicado: (2023)

Effects of oxiracetam combined with ginkgo biloba extract in the treatment of acute intracerebral hemorrhage: A clinical study
por: Li, Xiu‐Xiu, et al.
Publicado: (2020)

Microglial cathepsin E plays a role in neuroinflammation and amyloid β production in Alzheimer’s disease
por: Xie, Zhen, et al.
Publicado: (2022)

Interleukin-1β Drives Cellular Senescence of Rat Astrocytes Induced by Oligomerized Amyloid β Peptide and Oxidative Stress
por: Shang, Dongsheng, et al.
Publicado: (2020)

Microglial MAC1 receptor and PI3K are essential in mediating β-amyloid peptide-induced microglial activation and subsequent neurotoxicity
por: Zhang, Dan, et al.
Publicado: (2011)

Tau Ubiquitination in Alzheimer's Disease
por: Li, Longfei, et al.
Publicado: (2022)

Ketone Bodies in Neurological Diseases: Focus on Neuroprotection and Underlying Mechanisms
por: Yang, Huajun, et al.
Publicado: (2019)

Gypenoside Attenuates β Amyloid-Induced Inflammation in N9 Microglial Cells via SOCS1 Signaling
por: Cai, Hui, et al.
Publicado: (2016)

Lights for epilepsy: can photobiomodulation reduce seizures and offer neuroprotection?
por: Torres-Martinez, Napoleon, et al.
Publicado: (2022)

Blocking microglial activation of reactive astrocytes is neuroprotective in models of Alzheimer’s disease
por: Park, Jong-Sung, et al.
Publicado: (2021)

Ultrastructural evidence of microglial heterogeneity in Alzheimer’s disease amyloid pathology
por: El Hajj, Hassan, et al.
Publicado: (2019)

Near-infrared light reduces β-amyloid-stimulated microglial toxicity and enhances survival of neurons: mechanisms of light therapy for Alzheimer’s disease
por: Stepanov, Yurii V., et al.
Publicado: (2022)

Cerebral Amyloid Angiopathy-Related Inflammation in the Immunosuppressed: A Case Report
por: Nelson, Thomas, et al.
Publicado: (2019)

Amyloid-β breaks brain's neuroprotection
por: Wang, Yunling, et al.
Publicado: (2017)

Sinomenine inhibits microglial activation by Aβ and confers neuroprotection
por: Shukla, Shilpa Mishra, et al.
Publicado: (2011)

Endocannabinoid Modulation of Microglial Phenotypes in Neuropathology
por: Tanaka, Mikiei, et al.
Publicado: (2020)

Amyloid Beta Oligomers Target to Extracellular and Intracellular Neuronal Synaptic Proteins in Alzheimer's Disease
por: Ding, Yu, et al.
Publicado: (2019)

The amyloid imaging for the prevention of Alzheimer's disease consortium: A European collaboration with global impact
por: Collij, Lyduine E., et al.
Publicado: (2023)

Risk factors for recurrent cerebral amyloid angiopathy-related intracerebral hemorrhage
por: Jia, Xinglei, et al.
Publicado: (2023)

Cannabinoid CB2 Receptor Mediates Nicotine-Induced Anti-Inflammation in N9 Microglial Cells Exposed to β Amyloid via Protein Kinase C
por: Jia, Ji, et al.
Publicado: (2016)

Microglia in Alzheimer's Disease: Risk Factors and Inflammation
por: Katsumoto, Atsuko, et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_v5l4fd26tpsi1dbibrbun42evf