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N-acetycysteine: A potential therapeutic agent in COVID-19 infection

COVID-19 is an overwhelming pandemic which has shattered the whole world. Lung injury being the main clinical manifestation, it is likely to cause COPD (chronic obstructive pulmonary disease) and ARDS (acute respiratory distress syndrome). The possible cause behind this might be redox imbalance due...

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Detalles Bibliográficos
Autores principales: Jaiswal, N, Bhatnagar, M, Shah, H
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Ltd. 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7380211/
https://www.ncbi.nlm.nih.gov/pubmed/32758904
http://dx.doi.org/10.1016/j.mehy.2020.110133
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author Jaiswal, N
Bhatnagar, M
Shah, H
author_facet Jaiswal, N
Bhatnagar, M
Shah, H
author_sort Jaiswal, N
collection PubMed
description COVID-19 is an overwhelming pandemic which has shattered the whole world. Lung injury being the main clinical manifestation, it is likely to cause COPD (chronic obstructive pulmonary disease) and ARDS (acute respiratory distress syndrome). The possible cause behind this might be redox imbalance due to viral infection. Elevation in Glutathione (GSH) levels by administration of its promolecule might be effective. N-acetylcysteine is one such drug with potency to scavenge Reactive Oxygen Species, least side effects, and an effective precursor of glutathione. Consequently we hypothesize that N-acetylcysteine along with the conventional treatment may be treated as a potential therapeutic solution in cases of COVID-19 patients.
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spelling pubmed-73802112020-07-24 N-acetycysteine: A potential therapeutic agent in COVID-19 infection Jaiswal, N Bhatnagar, M Shah, H Med Hypotheses Article COVID-19 is an overwhelming pandemic which has shattered the whole world. Lung injury being the main clinical manifestation, it is likely to cause COPD (chronic obstructive pulmonary disease) and ARDS (acute respiratory distress syndrome). The possible cause behind this might be redox imbalance due to viral infection. Elevation in Glutathione (GSH) levels by administration of its promolecule might be effective. N-acetylcysteine is one such drug with potency to scavenge Reactive Oxygen Species, least side effects, and an effective precursor of glutathione. Consequently we hypothesize that N-acetylcysteine along with the conventional treatment may be treated as a potential therapeutic solution in cases of COVID-19 patients. Elsevier Ltd. 2020-11 2020-07-24 /pmc/articles/PMC7380211/ /pubmed/32758904 http://dx.doi.org/10.1016/j.mehy.2020.110133 Text en © 2020 Elsevier Ltd. All rights reserved. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Article
Jaiswal, N
Bhatnagar, M
Shah, H
N-acetycysteine: A potential therapeutic agent in COVID-19 infection
title N-acetycysteine: A potential therapeutic agent in COVID-19 infection
title_full N-acetycysteine: A potential therapeutic agent in COVID-19 infection
title_fullStr N-acetycysteine: A potential therapeutic agent in COVID-19 infection
title_full_unstemmed N-acetycysteine: A potential therapeutic agent in COVID-19 infection
title_short N-acetycysteine: A potential therapeutic agent in COVID-19 infection
title_sort n-acetycysteine: a potential therapeutic agent in covid-19 infection
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7380211/
https://www.ncbi.nlm.nih.gov/pubmed/32758904
http://dx.doi.org/10.1016/j.mehy.2020.110133
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