Cargando…
Acute-on-chronic liver failure: a single-centre experience
AIM OF THE STUDY: We set out to determine the applicability of acute-on-chronic liver failure (ACLF) diagnostic criteria and characteristics of thus defined ACLF sub-cohorts in a real-life clinical context. MATERIAL AND METHODS: Retrospective charts’ analysis of consecutive patients hospitalized wit...
Autores principales: | , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Termedia Publishing House
2020
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7380474/ https://www.ncbi.nlm.nih.gov/pubmed/32728625 http://dx.doi.org/10.5114/ceh.2020.96004 |
_version_ | 1783562861485752320 |
---|---|
author | Skladaný, Ľubomír Janceková, Daniela Vnenčáková, Janka Selčanová, Svetlana Adamcová Bystrianska, Natália Šváč, Juraj |
author_facet | Skladaný, Ľubomír Janceková, Daniela Vnenčáková, Janka Selčanová, Svetlana Adamcová Bystrianska, Natália Šváč, Juraj |
author_sort | Skladaný, Ľubomír |
collection | PubMed |
description | AIM OF THE STUDY: We set out to determine the applicability of acute-on-chronic liver failure (ACLF) diagnostic criteria and characteristics of thus defined ACLF sub-cohorts in a real-life clinical context. MATERIAL AND METHODS: Retrospective charts’ analysis of consecutive patients hospitalized with decompensated liver disease. Inclusion criteria: acute decompensation, informed consent. Exclusion criteria: malignancy. Diagnostic tools: 1(st) phase – CLIF-SOFA score calculated manually; 2(nd) phase – CLIF-C ACLF score calculated at www.efclif.com. RESULTS: Of 432 hospitalized patients aged 52 years, 41% were female, with MELD 20, 32% patients had acute decompensation (AD); main triggers were alcoholic hepatitis (38%), infections (26%), and variceal bleeding (23%). Of patients with AD, ACLF grades 0-3 was present in 64%, 19%, 13%, and 4%, respectively. In hospital mortality according to final AD/ACLF grade in ACLF 0-3 was 7.5%, 42%, 47%, and 80%, respectively (p < 0.0001). CONCLUSIONS: Diagnosing ACLF is nowadays easy; it helps to stratify patients at admission, and refine risk stratification at day 7. The main trigger of AD/ACLF in this region is alcohol. Currently, there are no ACLF-specific treatments; however, timely intensive supportive care can influence the prognosis. Even though still elusive and controversial, the ACLF concept can help systematize management of patients admitted with acute decompensation of advanced chronic liver disease. |
format | Online Article Text |
id | pubmed-7380474 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Termedia Publishing House |
record_format | MEDLINE/PubMed |
spelling | pubmed-73804742020-07-28 Acute-on-chronic liver failure: a single-centre experience Skladaný, Ľubomír Janceková, Daniela Vnenčáková, Janka Selčanová, Svetlana Adamcová Bystrianska, Natália Šváč, Juraj Clin Exp Hepatol Original Paper AIM OF THE STUDY: We set out to determine the applicability of acute-on-chronic liver failure (ACLF) diagnostic criteria and characteristics of thus defined ACLF sub-cohorts in a real-life clinical context. MATERIAL AND METHODS: Retrospective charts’ analysis of consecutive patients hospitalized with decompensated liver disease. Inclusion criteria: acute decompensation, informed consent. Exclusion criteria: malignancy. Diagnostic tools: 1(st) phase – CLIF-SOFA score calculated manually; 2(nd) phase – CLIF-C ACLF score calculated at www.efclif.com. RESULTS: Of 432 hospitalized patients aged 52 years, 41% were female, with MELD 20, 32% patients had acute decompensation (AD); main triggers were alcoholic hepatitis (38%), infections (26%), and variceal bleeding (23%). Of patients with AD, ACLF grades 0-3 was present in 64%, 19%, 13%, and 4%, respectively. In hospital mortality according to final AD/ACLF grade in ACLF 0-3 was 7.5%, 42%, 47%, and 80%, respectively (p < 0.0001). CONCLUSIONS: Diagnosing ACLF is nowadays easy; it helps to stratify patients at admission, and refine risk stratification at day 7. The main trigger of AD/ACLF in this region is alcohol. Currently, there are no ACLF-specific treatments; however, timely intensive supportive care can influence the prognosis. Even though still elusive and controversial, the ACLF concept can help systematize management of patients admitted with acute decompensation of advanced chronic liver disease. Termedia Publishing House 2020-06-10 2020-06 /pmc/articles/PMC7380474/ /pubmed/32728625 http://dx.doi.org/10.5114/ceh.2020.96004 Text en Copyright © 2020 Clinical and Experimental Hepatology http://creativecommons.org/licenses/by-nc-sa/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0). License (http://creativecommons.org/licenses/by-nc-sa/4.0/) |
spellingShingle | Original Paper Skladaný, Ľubomír Janceková, Daniela Vnenčáková, Janka Selčanová, Svetlana Adamcová Bystrianska, Natália Šváč, Juraj Acute-on-chronic liver failure: a single-centre experience |
title | Acute-on-chronic liver failure: a single-centre experience |
title_full | Acute-on-chronic liver failure: a single-centre experience |
title_fullStr | Acute-on-chronic liver failure: a single-centre experience |
title_full_unstemmed | Acute-on-chronic liver failure: a single-centre experience |
title_short | Acute-on-chronic liver failure: a single-centre experience |
title_sort | acute-on-chronic liver failure: a single-centre experience |
topic | Original Paper |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7380474/ https://www.ncbi.nlm.nih.gov/pubmed/32728625 http://dx.doi.org/10.5114/ceh.2020.96004 |
work_keys_str_mv | AT skladanylubomir acuteonchronicliverfailureasinglecentreexperience AT jancekovadaniela acuteonchronicliverfailureasinglecentreexperience AT vnencakovajanka acuteonchronicliverfailureasinglecentreexperience AT selcanovasvetlanaadamcova acuteonchronicliverfailureasinglecentreexperience AT bystrianskanatalia acuteonchronicliverfailureasinglecentreexperience AT svacjuraj acuteonchronicliverfailureasinglecentreexperience |