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Intrinsic ATR signaling shapes DNA end resection and suppresses toxic DNA-PKcs signaling

Most cancer cells experience oncogene-induced replication stress and, as a result, exhibit high intrinsic activation of the ATR kinase. Although cancer cells often become more dependent on ATR for survival, the precise mechanism by which ATR signaling ensures cancer cell fitness and viability remain...

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Detalles Bibliográficos
Autores principales:	Dibitetto, Diego, Sims, Jennie R, Ascenção, Carolline F R, Feng, Kevin, Kim, Dongsung, Oberly, Susannah, Freire, Raimundo, Smolka, Marcus B
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2020
Materias:	DNA Damage Sensing and Repair
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7380482/ https://www.ncbi.nlm.nih.gov/pubmed/32743550 http://dx.doi.org/10.1093/narcan/zcaa006

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