Clinical and functional characterization of CXCR1/CXCR2 biology in the relapse and radiotherapy resistance of primary PTEN-deficient prostate carcinoma

Functional impairment of the tumour suppressor PTEN is common in primary prostate cancer and has been linked to relapse post-radiotherapy (post-RT). Pre-clinical modelling supports elevated CXC chemokine signalling as a critical mediator of PTEN-depleted disease progression and therapeutic resistanc...

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Detalles Bibliográficos
Autores principales: Armstrong, Chris W D, Coulter, Jonathan A, Ong, Chee Wee, Maxwell, Pamela J, Walker, Steven, Butterworth, Karl T, Lyubomska, Oksana, Berlingeri, Silvia, Gallagher, Rebecca, O’Sullivan, Joe M, Jain, Suneil, Mills, Ian G, Prise, Kevin M, Bristow, Robert G, LaBonte, Melissa J, Waugh, David J J
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2020
Materias:
DNA Damage Sensing and Repair
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7380483/
https://www.ncbi.nlm.nih.gov/pubmed/32743555
http://dx.doi.org/10.1093/narcan/zcaa012

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